Staphylococcus aureus small-colony variants (SCVs) are associated with unusually chronic
and persistent infections despite active antibiotic treatment. The molecular basis for this …

Malaria is a disease that infects over 500 million people, causing at least 1 million deaths
every year, with the majority occurring in developing countries. The current antimalarial …

Successful control of falciparum malaria depends greatly on treatment with artemisinin
combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that …

Platelets restrict the growth of intraerythrocytic malaria parasites by binding to parasitized
cells and killing the parasite within. Here, we show that the platelet molecule platelet factor 4 (…

Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease. It is
thought that many common variant gene loci of weak effect act additively to predispose to …

Host recognition of microbial components is essential in mediating an effective immune
response. Cytosolic bacteria must secure entry into the host cytoplasm to facilitate replication and…

Many red cell polymorphisms are a result of selective pressure by the malarial parasite.
Here, we add another red cell disease to the panoply of erythrocytic changes that give rise to …

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a clear
genetic component. While most SLE patients carry rare gene variants in lupus risk genes, …

Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling
as a mechanism of human systemic autoimmune disease 1 , 2 , 3 , 4 , 5 , 6 – 7 , evidence of …

Inflammasomes are important for host defence against pathogens and homeostasis with
commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected …