Distal enhancers commonly contact target promoters via chromatin looping. In erythroid cells,
the locus control region (LCR) contacts β-type globin genes in a developmental stage-…

Recent advances in genomic research have revealed the existence of a large number of
transcripts devoid of protein-coding potential in multiple organisms 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 . …

Many enhancers exist as clusters in the genome, which has led to the coining of the term ‘super-enhancer’.
In this Viewpoint, five experts discuss our biological understanding of …

The laboratory mouse shares the majority of its protein-coding genes with humans, making
it the premier model organism in biomedical research, yet the two mammals differ in …

The transcription factor GATA-1 is essential for normal erythropoiesis. By examining in vitro–differentiated
embryonic stem cells, we showed previously that in the absence of GATA-1, …

The control of gene expression involves regulatory elements that can be very far from the
genes they control. Several recent technological advances have allowed the direct detection of …

It has been almost a quarter century since it was first appreciated that a class of oncogenes
contained in rapidly transforming avian retroviruses encoded DNA-binding transcription …

The transcription factor GATA-1 coordinates multiple events during terminal erythroid cell
maturation. GATA-1 participates in the transcription of virtually all erythroid-specific genes, …

Differentiation of pluripotent hematopoietic stem cells into mature circulating blood cells is
coordinated by a complex series of transcriptional events. During the last decade, numerous …

Tissue-specific transcription patterns are preserved throughout cell divisions to maintain
lineage fidelity. We investigated whether transcription factor GATA1 plays a role in transmitting …