Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

Estimation of narrow-sense heritability, h 2 , from genome-wide SNPs genotyped in unrelated
individuals has recently attracted interest and offers several advantages over traditional …

Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of complex …

Inference about the causal structure that induces correlations between two traits can be
achieved by combining genetic associations with a mediation-based approach, as is done in the …

Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely
widespread in the human genome. If pleiotropy arises because the single nucleotide …

10.7554/eLife.34408.001 Results from genome-wide association studies (GWAS) can be
used to infer causal relationships between phenotypes, using a strategy known as 2-sample …

Observational epidemiological studies are prone to confounding, reverse causation and
various biases and have generated findings that have proved to be unreliable indicators of the …

Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …