Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins
Mammalian genomes are spatially organized into compartments, topologically associating
domains (TADs), and loops to facilitate gene regulation and other chromosomal functions. …
domains (TADs), and loops to facilitate gene regulation and other chromosomal functions. …
DNA loop extrusion by human cohesin
IF Davidson, B Bauer, D Goetz, W Tang, G Wutz… - Science, 2019 - science.org
Eukaryotic genomes are folded into loops and topologically associating domains, which
contribute to chromatin structure, gene regulation, and gene recombination. These structures …
contribute to chromatin structure, gene regulation, and gene recombination. These structures …
Wapl is an essential regulator of chromatin structure and chromosome segregation
Mammalian genomes contain several billion base pairs of DNA that are packaged in chromatin
fibres. At selected gene loci, cohesin complexes have been proposed to arrange these …
fibres. At selected gene loci, cohesin complexes have been proposed to arrange these …
Transcription shapes 3D chromatin organization by interacting with loop extrusion
…, RR Stocsits, G Wutz… - Proceedings of the …, 2023 - National Acad Sciences
Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops. “Loop extrusion” can be impeded by chromatin-bound factors, such as CTCF, …
numerous loops. “Loop extrusion” can be impeded by chromatin-bound factors, such as CTCF, …
[PDF][PDF] Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism
BW Bauer, IF Davidson, D Canena, G Wutz, W Tang… - Cell, 2021 - cell.com
Structural maintenance of chromosomes (SMC) complexes organize genome topology in all
kingdoms of life and have been proposed to perform this function by DNA loop extrusion. …
kingdoms of life and have been proposed to perform this function by DNA loop extrusion. …
[HTML][HTML] CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion
In eukaryotes, genomic DNA is extruded into loops by cohesin 1 . By restraining this process,
the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically …
the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically …
[PDF][PDF] Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity
Topoisomerase II (TOP2) relieves torsional stress by forming transient cleavage complex
intermediates (TOP2ccs) that contain TOP2-linked DNA breaks (DSBs). While TOP2ccs are …
intermediates (TOP2ccs) that contain TOP2-linked DNA breaks (DSBs). While TOP2ccs are …
Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression
KG Wirth, G Wutz, NR Kudo, C Desdouets… - The Journal of cell …, 2006 - rupress.org
Separase is a protease whose liberation from its inhibitory chaperone Securin triggers sister
chromatid disjunction at anaphase onset in yeast by cleaving cohesin's kleisin subunit. We …
chromatid disjunction at anaphase onset in yeast by cleaving cohesin's kleisin subunit. We …
[PDF][PDF] Cohesin-dependent and-independent mechanisms mediate chromosomal contacts between promoters and enhancers
MJ Thiecke, G Wutz, M Muhar, W Tang, S Bevan… - Cell reports, 2020 - cell.com
It is currently assumed that 3D chromosomal organization plays a central role in transcriptional
control. However, depletion of cohesin and CTCF affects the steady-state levels of only a …
control. However, depletion of cohesin and CTCF affects the steady-state levels of only a …
Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion
Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimensional
organization of chromosomes at multiple levels, including compartments 1 and …
organization of chromosomes at multiple levels, including compartments 1 and …