… Hibret A. Adissu provided key mentorship in the preparation of this review article. The
authors acknowledge and appreciate thoughtful discussion and insights from Shelley Hoover, …

Advancements in technology and digitization have ushered in novel ways of enhancing
tissue-based research via digital microscopy and image analysis. Whole slide imaging scanners …

Effective combination chemotherapy requires the delivery of drugs of synergism to tumor
sites while sparing normal tissues. Herein we investigated whether coencapsulation of …

Background Basoapical polarity in epithelia is critical for proper tissue function, and control of
proliferation and survival. Cell culture models that recapitulate epithelial tissue architecture …

BACKGROUND Altered expression and activity of proteases is implicated in inflammation
and cancer progression. An important negative regulator of protease activity is TIMP3 (tissue …

In vitro 3-dimensional (3D) cell cultures produce valuable models that mimic 3D tissue
organization and function and enhance the understanding of cell/tissue function under normal …

Cleidocranial dysplasia (CCD) is an autosomal dominant human disorder characterized by
abnormal bone development that is mainly due to defective intramembranous bone …

The Mouse Genetics Project (MGP) at the Wellcome Trust Sanger Institute aims to generate
and phenotype over 800 genetically modified mouse lines over the next 5 years to gain a …

Melanomas arising in the mucous membranes are a rare and aggressive subtype. New
treatment approaches are needed, yet accumulating sufficient evidence to improve patient …

Dysregulation of Toll-like receptor (TLR) signaling contributes to the pathogenesis of
autoimmune diseases. Here, we provide genetic evidence that tankyrase, a member of the poly(…