A hallmark of schizophrenia pathophysiology is the dysfunction of cortical inhibitory GABA
neurons expressing parvalbumin, which are essential for coordinating neuronal synchrony …

Experience-dependent brain plasticity typically declines after an early critical period during
which circuits are established. Loss of plasticity with closure of the critical period limits …

The mechanisms by which common risk variants of small effect interact to contribute to
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …

Social cognition is a complex process that requires the integration of a wide variety of
behaviors, including salience, reward-seeking, motivation, knowledge of self and others, and …

Social isolation during the juvenile critical window is detrimental to proper functioning of the
prefrontal cortex (PFC) and establishment of appropriate adult social behaviors. However, …

Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits.
However, their precise function in the cerebellum is unknown. Here we show that human and …

Juvenile social isolation reduces sociability in adulthood, but the underlying neural circuit
mechanisms are poorly understood. We found that, in male mice, 2 weeks of social isolation …

Neural circuits are shaped by experience in early postnatal life. The permanent loss of
visual acuity (amblyopia) and anatomical remodeling within primary visual cortex following …

Protocadherins are predominantly expressed in the nervous system, and constitute the largest
subgroup within the cadherin superfamily. The recent structural elucidation of the amino-…

Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric
disorders including depression. In this study, we show that ELS in a postnatal sensitive …