Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …

Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has fueled
remarkable advances in our understanding of its potential neurobiological mechanisms. …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Three-dimensional physical interactions within chromosomes dynamically regulate gene
expression in a tissue-specific manner 1 , 2 , 3 . However, the 3D organization of chromosomes …

INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders, including
autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags …

Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by
impairments in social interaction and communication and restricted and repetitive interests/…

Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

Genetic studies have identified dozens of autism spectrum disorder (ASD) susceptibility
genes, raising two critical questions: (1) do these genetic loci converge on specific biological …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …