While tumor genome sequencing has become widely available in clinical and research
settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we …

Purpose: To evaluate the efficacy of treatment with the aromatase inhibitor letrozole in breast
cancer patients segregated with respect to DNA polymorphisms of the aromatase gene …

Aromatase inhibitor (AI)-associated arthralgia limits adherence to therapy in breast cancer.
The pathophysiology may involve vitamin D status. We wished to establish the optimal …

PURPOSE: The efficacy of adjuvant chemotherapy in gastric cancer is controversial. We
conducted a phase III, randomized, multicentric clinical trial with the goal of assessing the …

Overexpression of the human epidermal growth factor receptor 2 (HER2) defines a subgroup
of breast tumors with aggressive behavior. The addition of HER2-targeted antibodies (ie, …

Purpose: Trastuzumab-emtansine (T-DM1) is a standard treatment in advanced HER2-positive
breast cancer. However, resistance inevitably occurs. We aimed to identify mechanisms …

Aims: To compare different methods in order to assess adherence and persistence with oral
endocrine therapy in women diagnosed with breast cancer (BC) in Catalonia. Materials and …

Introduction One of the most common genetic aberrations associated with breast cancer is
the amplification and overexpression of the ERBB2 proto-oncogene located at chromosome …

Background: Most studies on endocrine-disrupting chemicals and breast cancer have focused
on single compounds and have produced inconclusive findings. Objectives: We assessed …

Objectives Assessing the combined effect of mammographic density and benign breast
disease is of utmost importance to design personalized screening strategies. Methods We …