We present rna22, a method for identifying microRNA binding sites and their corresponding
heteroduplexes. Rna22 does not rely upon cross-species conservation, is resilient to noise, …

The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly
550 million years ago. The modern ascidian tadpole represents a plausible approximation to …

MicroRNAs (miRNAs) are short RNAs that direct messenger RNA degradation or disrupt
mRNA translation in a sequence-dependent manner 1 , 2 , 3 , 4 , 5 , 6 , 7 . For more than a …

From the standpoints of both basic research and biotechnology, there is considerable interest
in reaching a clearer understanding of the diversity of biological mechanisms employed …

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

DNA methylation is a critical epigenetic regulator in mammalian development. Here, we
present a whole-genome comparative view of DNA methylation using bisulfite sequencing of …

Here, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for
common microRNAs, with microRNA response elements as the foundation of this interaction. …

MicroRNAs (miRNAs) are small regulatory RNAs that participate in posttranscriptional gene
regulation in a sequence-specific manner. However, little is understood about the role(s) of …

The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the cluster
and its members has been increasing steadily and the number of publications has grown …

Geometric hashing, a technique originally developed in computer vision for matching
geometric features against a database of such features, finds use in a number of other areas. …