Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and …

‘A peculiar severe disease process of the cerebral cortex' are the exact words used by A.
Alzheimer in 1906 to describe a patient’s increasingly severe condition of memory loss, …

Background Maturity-onset diabetes of the young (MODY) is an early-onset, autosomal
dominant form of non-insulin dependent diabetes. Genetic diagnosis of MODY can transform …

Background and Aim: Heterozygous inactivating mutations in the glucokinase (GCK) gene
cause a hyperglycemic condition termed maturity-onset diabetes of the young (MODY) 2 or …

Many organs and tissues have an intrinsic ability to regenerate from a dedicated, tissue-specific
stem cell pool. As organisms age, the process of self-regulation or homeostasis begins …

Objective This study describes the clinical and genetic evaluation of permanent neonatal
diabetes due to Wolcott–Rallison syndrome (WRS) in south Indian consanguineous families. …

Objective To study the etiology, clinical presentation and outcome of infantile onset diabetes
mellitus (IODM). Design Descriptive cohort study. Retrospective study from 1999–2007 and …

Congenital hyperinsulinemic hypoglycemia (HI) is a heterogeneous genetic disorder of
insulin secretion characterized by persistent hypoglycemia, most commonly associated with …

During animal development, complex signals determine and organize a vast number of
tissues using a very small number of signal transduction pathways. These developmental …

Mutations in the pancreatic ATP sensitive K + channel proteins [sulfonyluea receptor 1 (
SUR1 ) and inward rectifier K + channel Kir6.2 (Kir6.2), encoded by ATP‐binding cassette …