Resveratrol is a naturally occurring polyphenolic compound commonly found in plant‐derived
products, including red wine. A large number of beneficial effects including …

1. Abstract 2. Introduction 2.1. The role of mitochondrial DNA 2.1. 1. Mitochondrial DNA,
dysfunction and the etiology of age-dependent degenerative processes–insights and questions …

Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and …

The nematode worm Caenorhabditis elegans (C. elegans) is increasingly popular as a
model organism for aging studies as well as for testing antioxidants and other compounds for …

Progress towards structure determination that is both high-throughput and high-value is
dependent on the development of integrated and automatic tools for electron-density map …

Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds
that extend lifespan in model organisms is a growing research area. Here, we present …

β-Amyloid (Aβ)-induced toxicity and oxidative stress have been postulated to play critical
roles in the pathogenic mechanism of Alzheimer disease (AD). We investigated the in vivo …

Inhibition of the MDM2-p53 interaction has been shown to produce an antitumor effect,
especially in MDM2 amplified tumors. The isoindolinone scaffold has proved to be versatile for …

Populations in many nations today are rapidly ageing. This unprecedented demographic
change represents one of the main challenges of our time. A defining property of the ageing …

Contrasting observations have been made between serum urate and ischemic stroke
outcomes in studies involving Caucasian populations. To assess the hypothesis that urate is …