Cells respond to growth factors by either migrating or proliferating, but not both at the same
time, a phenomenon termed migration-proliferation dichotomy. The underlying mechanism of …

The zebrafish is emerging as a model organism for the safety assessment and hazard ranking
of engineered nanomaterials. In this Communication, the implementation of a roboticized …

Autophagy is the major catabolic process responsible for the removal of aggregated proteins
and damaged organelles. Autophagy is regulated by both G proteins and growth factors, …

Metastasis accounts for the majority of cancer-related deaths. Accurate prediction of
metastatic potential of tumors has been elusive, and the search for clinically useful markers …

Although several non-receptor activators of heterotrimeric G proteins have been identified,
the structural features of G proteins that determine their interaction with such activators and …

GIV (Gα-interacting vesicle-associated protein; also known as Girdin) enhances Akt
activation downstream of multiple growth factor– and G protein (heterotrimeric guanosine 5′-…

E-cigarette usage continues to rise, yet the safety of e-cigarette aerosols is questioned.
Using murine models of acute and chronic e-cigarette aerosol inhalation, murine colon …

A long-standing issue in the field of signal transduction is to understand the cross-talk between
receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major and distinct …

Calcium/calmodulin-dependent serine protein kinase (CASK) is a conserved multi-domain
scaffolding protein involved in brain development, synapse formation, and establishment of …

Diamond-Blackfan Anemia (DBA) is a bone marrow failure disorder characterized by low
red blood cell count. Mutations in ribosomal protein genes have been identified in …