The mammalian mitochondrial proteome is under dual genomic control, with 99% of
proteins encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA). …

Purpose Results of a prospective randomized trial conducted by the Intergroupe Francais
du Myé lome (IFM 90) indicated that autologous hematopoietic cell–supported high-dose …

Purpose Bronchioloalveolar carcinoma (BAC) and adenocarcinomas with BAC features seem
to be increasing in incidence, particularly in younger, never-smoking women. Epidermal …

Recently, many new drugs have been developed for the treatment of Waldenström
macroglobulinemia (WM). To optimize the treatment according to the prognosis and to facilitate the …

Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and introduces the first double
bond into saturated fatty acyl-CoAs 1 , 2 , 3 , 4 . Because the monounsaturated products of …

Cysteine dioxygenase (CDO) catalyzes the oxidation of l-cysteine to cysteine sulfinic acid.
Deficiencies in this enzyme have been linked to autoimmune diseases and neurological …

The ribonuclease inhibitor protein (RI) binds to members of the bovine pancreatic ribonuclease
(RNase A) superfamily with an affinity in the femtomolar range. Here, we report on …

Bile acids are synthesized from cholesterol in hepatocytes and secreted through the biliary
tract into the small intestine, where they aid in absorption of lipids and fat-soluble vitamins. …

Background Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members
of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a …

Purpose Tumor hypoxia confers chemotherapy resistance. Tirapazamine is a cytotoxin that
selectively targets hypoxic cells. We conducted a phase III clinical trial to determine whether …