10.7554/eLife.23326.001 Upon fertilization, the genome of animal embryos remains
transcriptionally inactive until the maternal-to-zygotic transition. At this time, the embryo takes control …

Background The second wave of the COVID-19 pandemic led to substantial differences in
incidence rates across Germany. Methods Assumption-free k-nearest neighbour clustering …

Inside the nucleus, DNA replication is organized at discrete sites called replication factories,
consisting of DNA polymerases and other replication proteins. Replication factories play …

A third SARS-CoV-2 infection wave has affected Germany from March 2021 until April 24th,
until the Bundesnotbremseintroduced nationwide shutdown measures. The …

As of late 2019, the COVID-19 pandemic has been a challenge to health care systems
worldwide. Rapidly rising local COVID-19 incidence rates, result in demand for high hospital and …

Radiotherapy can effectively kill malignant cells, but the doses required to cure cancer
patients may inflict severe collateral damage to adjacent healthy tissues. Recent technological …

Can three-dimensional, microvasculature networks still ensure blood supply if individual
links fail? We address this question in the sinusoidal network, a plexus-like microvasculature …

Motivated by multi-hop communication in unreliable wireless networks, we present a
percolation theory for time-varying networks. We develop a renormalization group theory for a …

DNA damage is a hazard all cells must face, and evolution has created a number of
mechanisms to repair damaged bases in the chromosome. Paradoxically, many of these repair …

DNA replication is an essential process in biology and its timing must be robust so that cells
can divide properly. Random fluctuations in the formation of replication starting points, called …