Molecular interactions at the cellular interface mediate organized assembly of single cells into
tissues and, thus, govern the development and physiology of multicellular organisms. Here…

In this work, we find that CD8 + T cells expressing inhibitory killer cell immunoglobulin-like
receptors (KIRs) are the human equivalent of Ly49 + CD8 + regulatory T cells in mice and are …

Mechanosensation, one of the fastest sensory modalities, mediates diverse behaviors including
those pertinent for survival. It is important to understand how mechanical stimuli trigger …

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

Highlights • Proximity labeling enables proteomic interrogation of the molecular components
of subcellular regions as well as protein interaction networks. • Proximity labeling has been …

The definition of neuronal type and how it relates to the transcriptome are open questions.
Drosophila olfactory projection neurons (PNs) are among the best-characterized neuronal …

How metazoan mechanotransduction channels sense mechanical stimuli is not well
understood. The NOMPC channel in the transient receptor potential (TRP) family, a …

T cells are a critical component of the response to SARS-CoV-2, but their kinetics after infection
and vaccination are insufficiently understood. Using "spheromer" peptide-MHC multimer …

Brain function requires precise neural circuit assembly during development. Establishing a
functional circuit involves multiple coordinated steps ranging from neural cell fate …

Cell-surface proteins (CSPs) mediate intercellular communication throughout the lives of
multicellular organisms. However, there are no generalizable methods for quantitative CSP …