Circular RNAs (circRNAs), formed by non-sequential back-splicing of pre-mRNA transcripts,
are a widespread form of non-coding RNA in animal cells. However, it is unclear whether …

A large proportion of the nitrate (NO 3 − ) acquired by plants from soil is actively transported
via members of the NRT families of NO 3 − transporters. In Arabidopsis, the NRT1 family has …

High expression of zinc ( Z n)‐regulated, iron‐regulated transporter‐like protein ( ZIP ) genes
increases root Z n uptake in dicots, leading to high accumulation of Z n in shoots. However, …

Pregnancy loss and perinatal death are devastating events for families. We assessed ‘genomic
autopsy’ as an adjunct to standard autopsy for 200 families who had experienced fetal or …

MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression,
functioning in part by facilitating the degradation of target mRNAs. They have an established role …

Members of the miR‐200 family are critical gatekeepers of the epithelial state, restraining
expression of pro‐mesenchymal genes that drive epithelial–mesenchymal transition ( EMT ) …

Acute myeloid leukemia (AML) is an aggressive malignancy where despite improvements in
conventional chemotherapy and bone marrow transplantation, overall survival remains poor…

Transcriptional enhancer elements are responsible for orchestrating the temporal and
spatial control over gene expression that is crucial for programming cell identity during …

Deep-sequencing reveals extensive variation in the sequence of endogenously expressed
microRNAs (termed ‘isomiRs’) in human cell lines and tissues, especially in relation to the 3…

Potent therapeutic inhibition of the androgen receptor (AR) in prostate adenocarcinoma can
lead to the emergence of neuroendocrine prostate cancer (NEPC), a phenomenon …