User profiles for Jon P. Boyle
Jon BoyleDepartment of Biological Sciences, University of Pittsburgh Verified email at pitt.edu Cited by 5561 |
Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host
Toxoplasma gondii is one of the most successful protozoan parasites owing to its ability to
manipulate the immune system and establish a chronic infection. There are many T. gondii …
manipulate the immune system and establish a chronic infection. There are many T. gondii …
Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence
Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, has the
unusual ability to infect virtually any warm-blooded animal. It is an extraordinarily successful …
unusual ability to infect virtually any warm-blooded animal. It is an extraordinarily successful …
[HTML][HTML] Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes
…, D Ajzenberg, JC Boothroyd, JP Boyle… - Nature …, 2016 - nature.com
Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild
and domestic animals and causing zoonotic infections in humans. T. gondii differs …
and domestic animals and causing zoonotic infections in humans. T. gondii differs …
Bioluminescence Imaging of Toxoplasma gondii Infection in Living Mice Reveals Dramatic Differences between Strains
We examined the in vivo growth, dissemination, and reactivation of strains of the protozoan
parasite Toxoplasma gondii using a bioluminescence-based imaging system. Two T. gondii …
parasite Toxoplasma gondii using a bioluminescence-based imaging system. Two T. gondii …
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole
The immunity‐related GTPases (IRGs) constitute an interferon‐induced intracellular
resistance mechanism in mice against Toxoplasma gondii. IRG proteins accumulate on the …
resistance mechanism in mice against Toxoplasma gondii. IRG proteins accumulate on the …
[HTML][HTML] Toxoplasma Effector MAF1 Mediates Recruitment of Host Mitochondria and Impacts the Host Response
Recent information has revealed the functional diversity and importance of mitochondria in
many cellular processes including orchestrating the innate immune response. Intriguingly, …
many cellular processes including orchestrating the innate immune response. Intriguingly, …
Using RNA interference to manipulate endogenous gene expression in Schistosoma mansoni sporocysts
Direct assessments of gene function in parasitic flatworms have been hampered by the lack
of effective tools to alter gene expression. The aim of the present study was to use RNA-…
of effective tools to alter gene expression. The aim of the present study was to use RNA-…
Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii
Toxoplasma gondii, an obligate intracellular protozoan of the phylum Apicomplexa, is estimated
to infect over a billion people worldwide as well as a great many other mammalian and …
to infect over a billion people worldwide as well as a great many other mammalian and …
Description of the Transcriptomes of Immune Response-Activated Hemocytes from the Mosquito Vectors Aedes aegypti and Armigeres subalbatus
…, JP Boyle, ET Beck, JF Fuchs, P Liss… - Infection and …, 2004 - Am Soc Microbiol
Mosquito-borne diseases, including dengue, malaria, and lymphatic filariasis, exact a
devastating toll on global health and economics, killing or debilitating millions every year (54). …
devastating toll on global health and economics, killing or debilitating millions every year (54). …
Age‐associated mortality in immune challenged mosquitoes (Aedes aegypti) correlates with a decrease in haemocyte numbers
JF Hillyer, SL Schmidt, JF Fuchs, JP Boyle… - Cellular …, 2005 - Wiley Online Library
Mosquitoes vector pathogens. One aspect that has been overlooked in mosquito–pathogen
relationships is the effect of host age on immune competence. Here, we show that there is …
relationships is the effect of host age on immune competence. Here, we show that there is …