In eukaryotes transcriptional regulation often involves multiple long-range elements and is
influenced by the genomic environment 1 . A prime example of this concerns the mouse X-…

Egg and sperm cells (gametes) of the mouse are derived from a founder population of
primordial germ cells that are set aside early in embryogenesis. Primordial germ cells arise from …

Biallelic expression of Igf2 is frequently seen in cancers because Igf2 functions as a survival
factor. In many tumors the activation of Igf2 expression has been correlated with de novo …

In somatic cells of female placental mammals, one X chromosome is inactivated to minimize
sex-related dosage differences of X-encoded genes. Random X chromosome inactivation (…

Evolution of the mammalian sex chromosomes has resulted in a heterologous X and Y pair,
where the Y chromosome has lost most of its genes. Hence, there is a need for X-linked …

Three-dimensional topology of DNA in the cell nucleus provides a level of transcription
regulation beyond the sequence of the linear DNA. To study the relationship between the …

Gene activation requires chromatin remodeling complexes, which hyperacetylate histones
and enable factor access; however, the targeting mechanisms leading to the establishment …

Murine pluripotent stem cells can exist in two functionally distinct states, LIF-dependent
embryonic stem cells (ESCs) and bFGF-dependent epiblast stem cells (EpiSCs). However, …

Hematopoietic progenitors undergo differentiation while navigating several cell division cycles,
but it is unknown whether these two processes are coupled. We addressed this question …

Progress in elucidating the molecular and cellular pathophysiology of neuropsychiatric
disorders has been hindered by the limited availability of living human brain tissue. The …