A fundamental goal in cancer research is to understand the mechanisms of cell transformation.
This is key to developing more efficient cancer detection methods and therapeutic …

The information about the genetic basis of human diseases lies at the heart of precision
medicine and drug discovery. However, to realize its full potential to support these goals, several …

DisGeNET is a comprehensive discovery platform designed to address a variety of questions
concerning the genetic underpinning of human diseases. DisGeNET contains over 380 …

While tumor genome sequencing has become widely available in clinical and research
settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we …

The IntOGen-mutations platform ( http://www.intogen.org/mutations/ ) summarizes somatic
mutations, genes and pathways involved in tumorigenesis. It identifies and visualizes cancer …

With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes
can now be undertaken in an unbiased manner. However, obtaining a complete catalog of …

Large efforts dedicated to detect somatic alterations across tumor genomes/exomes are
expected to produce significant improvements in precision cancer medicine. However, high inter-…

Somatic mutations are the driving force of cancer genome evolution 1 . The rate of somatic
mutations appears to be greatly variable across the genome due to variations in chromatin …

Distinguishing the driver mutations from somatic mutations in a tumor genome is one of the
major challenges of cancer research. This challenge is more acute and far from solved for …

Precision oncology relies on accurate discovery and interpretation of genomic variants,
enabling individualized diagnosis, prognosis and therapy selection. We found that six prominent …