User profiles for Joshua Chang Mell
 | Joshua Chang MellAssociate Professor, Drexel University College of Medicine Verified email at drexelmed.edu Cited by 2434 |
Natural competence and the evolution of DNA uptake specificity
JC Mell, RJ Redfield - Journal of bacteriology, 2014 - Am Soc Microbiol
Many bacteria are naturally competent, able to actively transport environmental DNA fragments
across their cell envelope and into their cytoplasm. Because incoming DNA fragments …
across their cell envelope and into their cytoplasm. Because incoming DNA fragments …
Art and the brain: the influence of frontotemporal dementia on an accomplished artist
JC Mell, SM Howard, BL Miller - Neurology, 2003 - AAN Enterprises
A talented artist developed a progressive aphasia syndrome associated with frontotemporal
dementia (FTD). As her disease progressed, language and executive skills declined, but her …
dementia (FTD). As her disease progressed, language and executive skills declined, but her …
[HTML][HTML] Species-level bacterial community profiling of the healthy sinonasal microbiome using Pacific Biosciences sequencing of full-length 16S rRNA genes
Background Pan-bacterial 16S rRNA microbiome surveys performed with massively parallel
DNA sequencing technologies have transformed community microbiological studies. …
DNA sequencing technologies have transformed community microbiological studies. …
[HTML][HTML] Transformation of Natural Genetic Variation into Haemophilus Influenzae Genomes
Many bacteria are able to efficiently bind and take up double-stranded DNA fragments, and
the resulting natural transformation shapes bacterial genomes, transmits antibiotic resistance…
the resulting natural transformation shapes bacterial genomes, transmits antibiotic resistance…
[HTML][HTML] Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG
…, AJ Fike, JL Thayer, LT Nguyen, JC Mell… - PLoS …, 2019 - journals.plos.org
Respiratory viral infections contribute substantially to global infant losses and disproportionately
affect preterm neonates. Using our previously established neonatal murine model of …
affect preterm neonates. Using our previously established neonatal murine model of …
Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs
Chronic bacterial infections of the lung are the leading cause of morbidity and mortality in
cystic fibrosis patients. Tracking bacterial evolution during chronic infections can provide …
cystic fibrosis patients. Tracking bacterial evolution during chronic infections can provide …
Antagonistic pleiotropy in the bifunctional surface protein FadL (OmpP1) during adaptation of Haemophilus influenzae to chronic lung infection associated with chronic …
Tracking bacterial evolution during chronic infection provides insights into how host
selection pressures shape bacterial genomes. The human-restricted opportunistic pathogen …
selection pressures shape bacterial genomes. The human-restricted opportunistic pathogen …
Defining the DNA uptake specificity of naturally competent Haemophilus influenzae cells
Some naturally competent bacteria exhibit both a strong preference for DNA fragments
containing specific ‘uptake sequences’ and dramatic overrepresentation of these sequences in …
containing specific ‘uptake sequences’ and dramatic overrepresentation of these sequences in …
Extensive Cotransformation of Natural Variation into Chromosomes of Naturally Competent Haemophilus influenzae
Naturally competent bacterial species actively take up environmental DNA and can incorporate
it into their chromosomes by homologous recombination. This can bring genetic variation …
it into their chromosomes by homologous recombination. This can bring genetic variation …
Broad-spectrum and personalized guide RNAs for CRISPR/Cas9 HIV-1 therapeutics
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9
system has been used to excise the HIV-1 proviral genome from latently infected cells, …
system has been used to excise the HIV-1 proviral genome from latently infected cells, …