Peptide sequence analysis using a combination of gas-phase ion/ion chemistry and tandem
mass spectrometry (MS/MS) is demonstrated. Singly charged anthracene anions transfer an …

We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …

Selected reaction monitoring on a triple quadrupole mass spectrometer is currently experiencing
a renaissance within the proteomics community for its, as yet, unparalleled ability to …

Lignin is a heterogeneous aromatic biopolymer that accounts for nearly 30% of the organic
carbon on Earth 1 and is one of the few renewable sources of aromatic chemicals 2 . As the …

Calorie restriction (CR) extends life span in diverse species. Mitochondria play a key role in
CR adaptation; however, the molecular details remain elusive. We developed and applied a …

We present a strategy for the analysis of the yeast phosphoproteome that uses endo-Lys C
as the proteolytic enzyme, immobilized metal affinity chromatography for phosphopeptide …

Mass spectrometry has played an integral role in the identification of proteins and their post-translational
modifications (PTM). However, analysis of some PTMs, such as phosphorylation…

We describe the comprehensive analysis of the yeast proteome in just over one hour of
optimized analysis. We achieve this expedited proteome characterization with improved sample …

A method for rapid sequencing of intact proteins simultaneously from the N and C termini (1–2
s) with online chromatography is described and applied to the characterization of histone …

An average shotgun proteomics experiment detects approximately 10,000 human proteins
from a single sample. However, individual proteins are typically identified by peptide …