The central event in the cellular immune response to invading microorganisms is the specific
recognition of foreign peptides bound to major histocompatibility complex (MHC) molecules …

DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of
Structure Prediction (CASP14) conference. We explored network architectures that …

Recent structural information for complexes of cytokine receptor ectodomains bound to their
ligands has significantly expanded our understanding of the macromolecular topology and …

Cancer immunotherapy based on genetically redirecting T cells has been used successfully
to treat B cell malignancies 1 , 2 – 3 . In this strategy, the T cell genome is modified by …

Cytokines are secreted signalling proteins that play essential roles in the initiation, maintenance
and resolution of immune responses. Although the unique ability of cytokines to control …

Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …

The design of proteins that bind to a specific site on the surface of a target protein using no
information other than the three-dimensional structure of the target remains a challenge 1 , 2 , …

Interleukin 35 (IL-35) belongs to the IL-12 family of heterodimeric cytokines but has a distinct
functional profile. IL-35 suppresses T cell proliferation and converts naive T cells into IL-35-…

Interleukin-4 and Interleukin-13 are cytokines critical to the development of T cell-mediated
humoral immune responses, which are associated with allergy and asthma, and exert their …

G-protein-coupled receptors (GPCRs) are integral membrane proteins that have an essential
role in human physiology, yet the molecular processes through which they bind to their …