Obesity and type 2 diabetes (T2D) are associated with low-grade inflammation, activation of
immune cells, and alterations of the gut microbiota. Mucosal-associated invariant T (MAIT) …

Leptin resistance and obesity have been related to mutations of the leptin receptor gene in
rodents and, recently, in a consanguineous family. The latter mutation results in a receptor …

The adipocyte-specific hormone leptin, the product of the obese (ob) gene,regulates
adipose-tissue mass through hypothalamic effects on satiety and energy expenditure 1 , 2 , 3 , 4 . …

OBJECTIVE Obesity alters gut microbiota ecology and associates with low-grade
inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient …

Adipose tissue produces inflammation and immunity molecules suspected to be involved in
obesity‐related complications. The pattern of expression and the nutritional regulation of …

Background The β 3 -adrenergic receptor, located mainly in adipose tissue, is involved in
the regulation of lipolysis and thermogenesis. The potential relevance of this receptor to …

Complex gene–environment interactions are considered important in the development of
obesity 1 . The composition of the gut microbiota can determine the efficacy of energy harvest …

In human obesity, the stroma vascular fraction (SVF) of white adipose tissue (WAT) is
enriched in macrophages. These cells may contribute to low-grade inflammation and to its …

We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we
report the human gut microbial composition in a population sample of 123 non-obese and 169 …

Adiponectin (ACRP30), an adipocyte-secreted protein encoded by the APM1 gene, is known
to modulate insulin sensitivity and glucose homeostasis, those effects protecting obese …