[HTML][HTML] Prenatal smoking might not cause attention-deficit/hyperactivity disorder: evidence from a novel design

A Thapar, F Rice, D Hay, J Boivin, K Langley… - Biological …, 2009 - Elsevier
BACKGROUND: It is widely considered that exposure to maternal cigarette smoking in pregnancy
has risk effects on offspring attention-deficit/hyperactivity disorder (ADHD). This view is …

Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder

K Langley, T Fowler, T Ford, AK Thapar… - The British Journal of …, 2010 - cambridge.org
BackgroundAttention-deficit hyperactivity disorder (ADHD) is recognised as a common,
disabling condition. Little information is available regarding the long-term outcomes for …

Practitioner review: what have we learnt about the causes of ADHD?

…, M Cooper, O Eyre, K Langley - Journal of Child …, 2013 - Wiley Online Library
Background: Attention deficit hyperactivity disorder (ADHD) and its possible causes still
attract controversy. Genes, pre and perinatal risks, psychosocial factors and environmental …

Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder

A Thapar, K Langley, T Fowler, F Rice… - Archives of general …, 2005 - jamanetwork.com
Context Early-onset antisocial behavior accompanied by attention-deficit/hyperactivity disorder
is a clinically severe variant of antisocial behavior that is associated with a particularly …

Gene–environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective

A Thapar, K Langley, P Asherson… - The British Journal of …, 2007 - cambridge.org
Attention-deficit hyperactivity disorder (ADHD) varies in its clinical presentation and course.
Susceptibility gene variants for ADHD and associated antisocial behaviour are being …

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

…, J Haavik, HR Kranzler, J Kuntsi, K Langley… - Nature …, 2019 - nature.com
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

[PDF][PDF] Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders

…, DP Howrigan, H Huang, J Kuntsi, K Langley… - Cell, 2019 - cell.com
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

[HTML][HTML] Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis

NM Williams, I Zaharieva, A Martin, K Langley… - The Lancet, 2010 - thelancet.com
Background Large, rare chromosomal deletions and duplications known as copy number
variants (CNVs) have been implicated in neurodevelopmental disorders similar to attention-…

Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13. 3

…, AA Vasquez, Z Hawi, K Langley… - American Journal of …, 2012 - Am Psychiatric Assoc
Objective: Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable
psychiatric disorder. Because of its multifactorial etiology, however, identifying the genes involved …

Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.

K Langley, F Rice, MB van den Bree, A Thapar - Minerva pediatrica, 2005 - europepmc.org
Attention deficit hyperactivity disorder (ADHD) is a common childhood psychiatric disorder
which affects between 3% and 5% of school aged children. Despite much research, little is …