Insulin resistance, a critical component of type 2 diabetes (T2D), precedes and predicts T2D
onset. T2D is also associated with mitochondrial dysfunction. To define the cause-effect …

RNA sequencing (RNA-seq) is becoming a prevalent approach to quantify gene expression
and is expected to gain better insights into a number of biological and biomedical questions …

Insulin resistance is central to diabetes and metabolic syndrome. To define the consequences
of genetic insulin resistance distinct from those secondary to cellular differentiation or in …

The extent to which the genes are expressed in the cell can be simplistically defined as a
function of one or more factors of the environment, lifestyle, and genetics. RNA sequencing (…

Cancer is a leading cause of death worldwide, resulting in an estimated 1.6 million mortalities
and 600,000 new cases in the US alone in 2015. Gene fusions, hybrid genes formed from …

The current study examined (1) changes in psychosocial adjustment among adolescents
completing two surveys before COVID‐19 and those completing the final survey during COVID‐…

Background US Army Basic Combat Training (BCT) is a physically-demanding program at
the start of military service. Whereas animal studies have shown that increased mechanical …

We review evidence supporting an updated mechanostat model in bone that highlights the
central role of osteocytes within bone's four mechanoadaptive pathways: 1) formation …

Stress fractures are common in military personnel and endurance athletes, and nonsteroidal
anti‐inflammatory drug (NSAID) use is widespread in these populations. NSAIDs inhibit …

Hormones and mechanical loading co-regulate bone throughout the lifespan. In this review,
we posit that times of increased hormonal influence on bone provide opportunities for …