Methods for detecting nucleotide substitution rates that are faster or slower than expected
under neutral drift are widely used to identify candidate functional elements in genomic …

Our growing awareness of the microbial world’s importance and diversity contrasts starkly
with our limited understanding of its fundamental structure. Despite recent advances in DNA …

Comprehensive, high-quality reference genomes are required for functional characterization
and taxonomic assignment of the human gut microbiota. We present the Unified Human …

The December 2019 outbreak of a novel respiratory virus, SARS-CoV-2, has become an
ongoing global pandemic due in part to the challenge of identifying symptomatic, asymptomatic, …

The comparison of related genomes has emerged as a powerful lens for genome interpretation.
Here we report the sequencing and comparative analysis of 29 eutherian genomes. We …

The developmental and evolutionary mechanisms behind the emergence of human-specific
brain features remain largely unknown. However, the recent ability to compare our genome …

Although much work has linked the human microbiome to specific phenotypes and lifestyle
variables, data from different projects have been challenging to integrate and the extent of …

Heart development is exquisitely sensitive to the precise temporal regulation of thousands
of genes that govern developmental decisions during differentiation. However, we currently …

The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 …

The genome sequences of many species of the human gut microbiome remain unknown,
largely owing to challenges in cultivating microorganisms under laboratory conditions. Here …