Epithelial‐to‐mesenchymal transition ( EMT ) and its reverse mesenchymal‐to‐epithelial
transition ( MET ) have been suggested to play crucial roles in metastatic dissemination of …

Despite widespread expression of epidermal growth factor (EGF) receptors (EGFRs) and
EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific tyrosine kinase …

Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs,
nearly all will develop resistance and relapse. Gene expression analysis of NSCLC cell lines …

Purpose: FGFR1 gene copy number (GCN) is being evaluated as a biomarker for FGFR tyrosine
kinase inhibitor (TKI) response in squamous cell lung cancers (SCC). The exclusive use …

As prostate cancer (PCa) progresses to the lethal castration resistant and metastatic form,
genetic and epigenetic adaptation, clonal selection, and evolution of the tumor …

Purpose: We previously reported that a fibroblast growth factor (FGF) receptor (FGFR) signaling
pathway drives growth of lung cancer cell lines of squamous and large cell histologies. …

Phenotypic plasticity involves a process in which cells transiently acquire phenotypic traits
of another lineage. Two commonly studied types of phenotypic plasticity are epithelial-…

Oncogenic kinase fusions of ALK, ROS1, RET, and NTRK1 act as drivers in human lung and
other cancers. Residual tumor burden following treatment of ALK or ROS1 + lung cancer …

Purpose: Beyond enumeration, circulating tumor cells (CTCs) can provide genetic information
from metastatic cancer that may facilitate a greater understanding of tumor biology and …

… MK Jolly and KE Ware contributed equally to and are the co-first authors of this article. …
Because membrane E-cadherin is the most typically characterized aspect of E-cadherin function, …