Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins, …

Adult mesenchymal stem cells secrete a variety of angiogenic cytokines and growth factors,
so we proposed that these paracrine mechanisms may be used to promote vascularization …

It is now well recognized that mutations, deregulated expression, and aberrant recruitment
of epigenetic readers, writers, and erasers are fundamentally important processes in the …

10.7554/eLife.26980.001 Recent genome analyses have identified recurrent mutations in
the cohesin complex in a wide range of human cancers. Here we demonstrate that the most …

Histone deacetylase (HDAC) inhibitors (HDACis) have demonstrated activity in hematological
and solid malignancies. Vorinostat, romidepsin, belinostat, and panobinostat are Food …

Identification of mechanisms of resistance to histone deacetylase inhibitors, such as vorinostat,
is important in order to utilise these anticancer compounds more efficiently in the clinic. …

Cell death is integral to developmental and disease processes, and high-throughput screening
(HTS) has been instrumental both for understanding biological mechanisms underlying …

This protocol outlines a high-throughput, multiplex cell death assay and its use in conjunction
with a genome-scale siRNA screen to identify genes that cooperate with a drug to induce …

It is now well recognised that mutations, de-regulated expression and aberrant recruitment
of epigenetic readers, writers and erasers is a fundamentally important process in the onset …

Recent genome analyses have identified recurrent mutations in the cohesin complex in a
wide range of human cancers. Here we demonstrate that the most frequently mutated subunit …