10.7554/eLife.28899.001 Here we report multiple lines of evidence for a comprehensive model
of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and …

Symbiotic relationships between neurons and glia must adapt to structures, functions, and
metabolic roles of the tissues they are in. We show here that Müller glia in retinas have …

Staphylococcus aureus is an important human commensal and opportunistic pathogen
responsible for a wide range of infections. Long chain unsaturated free fatty acids represent a …

The vertebrate retina has specific functions and structures that give it a unique set of constraints
on the way in which it can produce and use metabolic energy. The retina's response to …

Production of energy in a cell must keep pace with demand. Photoreceptors use ATP to
maintain ion gradients in darkness, whereas in light they use it to support phototransduction. …

Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that is expressed in cancer cells. Its role
in tumor metabolism is not definitively established, but investigators have suggested that …

An Expert System is being developed to perform generative process planning for individual
parts fabricated from extruded and sheet metal materials, and for bonded metal assemblies. …

The identification and characterisation of faults in urban environments is important to inform
seismic and landslide hazard, yet urban development often obscures geological and …

Purpose: Glucose transport is central to retinal metabolism and health, particularly for highly
glycolytic photoreceptors, and many retinal cell types make limited or no contacts with the …

Purpose: Identifying the metabolic fuels used by neurons and glia in the retina is of fundamental
importance for understanding retinal function and viability. In a previous study 1 we …