Cohesins mediate sister chromatid cohesion, which is essential for chromosome segregation
and postreplicative DNA repair. In addition, cohesins appear to regulate gene expression …

The mechanisms that specify precisely where mammalian kinetochores form within arrays of
centromeric heterochromatin remain largely unknown. Localization of CENP-A exclusively …

Nucleosomal DNA is arranged in a higher-order structure that presents a barrier to most
cellular processes involving protein DNA interactions 1 . The cellular machinery involved in …

Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy in
which no mutation of pathogenic gene(s) has been identified. Instead, the disease is, in most …

Damage recognition by repair/checkpoint factors is the critical first step of the DNA damage
response. DNA double strand breaks (DSBs) activate checkpoint signaling and are repaired …

The mechanisms that govern core promoter recognition and basal transcription efficiency
remain poorly understood. Here, we have assessed the potential role of TAFs and the TFIID …

Cohesin is a conserved multiprotein complex that plays an essential role in sister chromatid
cohesion. During interphase, cohesin is required for the establishment of cohesion following …

Cornelia de Lange Syndrome (CdLS) is a multi-organ system birth defects disorder linked,
in at least half of cases, to heterozygous mutations in the NIPBL gene. In animals and fungi, …

Proper recognition and repair of DNA damage is critical for the cell to protect its genomic
integrity. Laser microirradiation ranging in wavelength from ultraviolet A (UVA) to near-infrared (…

We previously reported that transcriptional regulators can bind selected TAF subunits of the
TFIID complex. However, the specificity and function of individual TAFs in mediating …