User profiles for Lee-Yuan Liu-Chen
 | Lee-Yuan Liu-ChenTemple University Lewis Katz School of Medicine Verified email at temple.edu Cited by 10505 |
Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites
…, C Hoffer, L Risler, LY Liu‐Chen… - Clinical …, 2006 - Wiley Online Library
Background In vitro experiments suggest that circulating metabolites of oxycodone are
opioid receptor agonists. Clinical and animal studies to date have failed to demonstrate a …
opioid receptor agonists. Clinical and animal studies to date have failed to demonstrate a …
Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist
P Huang, GB Kehner, A Cowan, LY Liu-Chen - Journal of Pharmacology and …, 2001 - ASPET
Buprenorphine (BUP) is an oripavine analgesic that is beneficial in the maintenance treatment
of opiate-dependent individuals. Although BUP has been studied extensively, relatively …
of opiate-dependent individuals. Although BUP has been studied extensively, relatively …
Comparison of pharmacological activities of three distinct κ ligands (salvinorin A, TRK-820 and 3FLB) on κ opioid receptors in vitro and their antipruritic and …
…, P Huang, JG Li, A Cowan, LY Liu-Chen - … of Pharmacology and …, 2005 - ASPET
Salvinorin A, TRK-820 (17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)
acrylamido]morphinan hydrochloride), and 3FLB (diethyl 2,4-di-[3-fluorophenyl]-…
acrylamido]morphinan hydrochloride), and 3FLB (diethyl 2,4-di-[3-fluorophenyl]-…
Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior
…, C Isiegas, P Huang, LY Liu-Chen… - Proceedings of the …, 2009 - National Acad Sciences
A single nucleotide polymorphism (SNP) in the human μ-opioid receptor gene (OPRM1
A118G) has been widely studied for its association in a variety of drug addiction and pain …
A118G) has been widely studied for its association in a variety of drug addiction and pain …
Heterodimerization and cross-desensitization between the μ-opioid receptor and the chemokine CCR5 receptor
…, J Li, G Bot, I Szabo, TJ Rogers, LY Liu-Chen - European journal of …, 2004 - Elsevier
Cross-desensitization between μ-opioid receptor agonists and CC chemokines was shown
to occur in immune cells and in the central nervous system. However, these cells do not …
to occur in immune cells and in the central nervous system. However, these cells do not …
The association of NHERF adaptor proteins with G protein–coupled receptors and receptor tyrosine kinases
…, RA Hall, PA Friedman, LY Liu-Chen… - Annu. Rev …, 2006 - annualreviews.org
▪ Abstract The sodium-hydrogen exchanger regulatory factors (NHERF-1 and NHERF-2) are
a family of adaptor proteins characterized by the presence of two tandem PDZ protein …
a family of adaptor proteins characterized by the presence of two tandem PDZ protein …
A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability
…, SD Mague, JA Blendy, LY Liu-Chen - Biochemical …, 2012 - portlandpress.com
The A118G SNP (single nucleotide polymorphism) of the hMOPR [human MOPR (μ opioid
receptor)] gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous …
receptor)] gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous …
[HTML][HTML] 6′-Guanidinonaltrindole (6′-GNTI) is a G protein-biased κ-opioid receptor agonist that inhibits arrestin recruitment
ML Rives, M Rossillo, LY Liu-Chen… - Journal of Biological …, 2012 - ASBMB
κ-Opioid receptor (KOR) agonists do not activate the reward pathway stimulated by
morphine-like μ-opioid receptor (MOR) agonists and thus have been considered to be promising …
morphine-like μ-opioid receptor (MOR) agonists and thus have been considered to be promising …
Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation
…, E Yuvasheva, YT Chiu, AB Reitz, LY Liu-Chen… - Drug and alcohol …, 2012 - Elsevier
Abuse of a dangerous street drug called mephedrone (4-methylmethcathinone) has become
commonplace in the United States. Mephedrone is hypothesized to possess abuse liability, …
commonplace in the United States. Mephedrone is hypothesized to possess abuse liability, …
Activation of the cloned human kappa opioid receptor by agonists enhances [35S] GTPγS binding to membranes: determination of potencies and efficacies of ligands
J Zhu, LY Luo, JG Li, C Chen, LY Liu-Chen - Journal of Pharmacology and …, 1997 - ASPET
Activation of kappa receptors inhibits adenylate cyclase, enhances K + conductance and
reduces Ca ++ conductance via pertussis toxin-sensitive G proteins. We recently cloned a …
reduces Ca ++ conductance via pertussis toxin-sensitive G proteins. We recently cloned a …