User profiles for Lexiang Ji
 | Lexiang JiSenior Expert I Data Science at Novartis Verified email at novartis.com Cited by 3088 |
[HTML][HTML] Widespread natural variation of DNA methylation within angiosperms
Background DNA methylation is an important feature of plant epigenomes, involved in the
formation of heterochromatin and affecting gene expression. Extensive variation of DNA …
formation of heterochromatin and affecting gene expression. Extensive variation of DNA …
[HTML][HTML] Nociceptor neurons affect cancer immunosurveillance
Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory
peripheral nervous systems 1 , 2 , 3 , 4 – 5 . Whether the neo-innervation of tumours by pain-…
peripheral nervous systems 1 , 2 , 3 , 4 – 5 . Whether the neo-innervation of tumours by pain-…
On the origin and evolutionary consequences of gene body DNA methylation
AJ Bewick, L Ji, CE Niederhuth… - Proceedings of the …, 2016 - National Acad Sciences
In plants, CG DNA methylation is prevalent in the transcribed regions of many constitutively
expressed genes (gene body methylation; gbM), but the origin and function of gbM remain …
expressed genes (gene body methylation; gbM), but the origin and function of gbM remain …
Widespread long-range cis-regulatory elements in the maize genome
Genetic mapping studies on crops suggest that agronomic traits can be controlled by gene–distal
intergenic loci. Despite the biological importance and the potential agronomic utility of …
intergenic loci. Despite the biological importance and the potential agronomic utility of …
[PDF][PDF] Crop epigenomics: identifying, unlocking, and harnessing cryptic variation in crop genomes
DNA methylation is a key chromatin modification in plant genomes that is meiotically and
mitotically heritable, and at times is associated with gene expression and morphological …
mitotically heritable, and at times is associated with gene expression and morphological …
Subgenome dominance in an interspecific hybrid, synthetic allopolyploid, and a 140-year-old naturally established neo-allopolyploid monkeyflower
Recent studies have shown that one of the parental subgenomes in ancient polyploids is
generally more dominant, having retained more genes and being more highly expressed, a …
generally more dominant, having retained more genes and being more highly expressed, a …
[HTML][HTML] Genomic distribution of H3K9me2 and DNA methylation in a maize genome
DNA methylation and dimethylation of lysine 9 of histone H3 (H3K9me2) are two chromatin
modifications that can be associated with gene expression or recombination rate. The maize …
modifications that can be associated with gene expression or recombination rate. The maize …
Maize death acids, 9-lipoxygenase–derived cyclopente (a) nones, display activity as cytotoxic phytoalexins and transcriptional mediators
…, S Ziemann, G Doehlemann, L Ji… - Proceedings of the …, 2015 - National Acad Sciences
Plant damage promotes the interaction of lipoxygenases (LOXs) with fatty acids yielding 9-hydroperoxides,
13-hydroperoxides, and complex arrays of oxylipins. The action of 13-LOX on …
13-hydroperoxides, and complex arrays of oxylipins. The action of 13-LOX on …
[HTML][HTML] Full-length autonomous transposable elements are preferentially targeted by expression-dependent forms of RNA-directed DNA methylation
Background Chromatin modifications such as DNA methylation are targeted to transposable
elements by small RNAs in a process termed RNA-directed DNA methylation (RdDM). In …
elements by small RNAs in a process termed RNA-directed DNA methylation (RdDM). In …
[HTML][HTML] The evolution of CHROMOMETHYLASES and gene body DNA methylation in plants
AJ Bewick, CE Niederhuth, L Ji, NA Rohr, PT Griffin… - Genome biology, 2017 - Springer
Background The evolution of gene body methylation (gbM), its origins, and its functional
consequences are poorly understood. By pairing the largest collection of transcriptomes (>1000…
consequences are poorly understood. By pairing the largest collection of transcriptomes (>1000…