[HTML][HTML] Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line
IA Maksakova, MT Romanish, L Gagnier, CA Dunn… - PLoS …, 2006 - journals.plos.org
The inbred mouse is an invaluable model for human biology and disease. Nevertheless, when
considering genetic mechanisms of variation and disease, it is important to appreciate the …
considering genetic mechanisms of variation and disease, it is important to appreciate the …
[HTML][HTML] Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms
The “arms race” relationship between transposable elements (TEs) and their host has promoted
a series of epigenetic silencing mechanisms directed against TEs. Retrotransposons, a …
a series of epigenetic silencing mechanisms directed against TEs. Retrotransposons, a …
[HTML][HTML] Mouse germ line mutations due to retrotransposon insertions
L Gagnier, VP Belancio, DL Mager - Mobile DNA, 2019 - Springer
Transposable element (TE) insertions are responsible for a significant fraction of spontaneous
germ line mutations reported in inbred mouse strains. This major contribution of TEs to the …
germ line mutations reported in inbred mouse strains. This major contribution of TEs to the …
Genomic deletions and precise removal of transposable elements mediated by short identical DNA segments in primates
LN van de Lagemaat, L Gagnier, P Medstrand… - Genome …, 2005 - genome.cshlp.org
Insertion of transposable elements is a major cause of genomic expansion in eukaryotes.
Less is understood, however, about mechanisms underlying contraction of genomes. In this …
Less is understood, however, about mechanisms underlying contraction of genomes. In this …
[HTML][HTML] Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements
Y Zhang, IA Maksakova, L Gagnier… - PLoS …, 2008 - journals.plos.org
Endogenous retroviral elements (ERVs) in mice are significant genomic mutagens, causing
∼10% of all reported spontaneous germ line mutations in laboratory strains. The majority of …
∼10% of all reported spontaneous germ line mutations in laboratory strains. The majority of …
Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma
…, R Rebollo, K Miceli-Royer, L Gagnier… - Proceedings of the …, 2014 - National Acad Sciences
Remnants of ancient transposable elements (TEs) are abundant in mammalian genomes.
These sequences harbor multiple regulatory motifs and hence are capable of influencing …
These sequences harbor multiple regulatory motifs and hence are capable of influencing …
[HTML][HTML] Epigenetic interplay between mouse endogenous retroviruses and host genes
…, K Miceli-Royer, Y Zhang, S Farivar, L Gagnier… - Genome biology, 2012 - Springer
Background Transposable elements are often the targets of repressive epigenetic modifications
such as DNA methylation that, in theory, have the potential to spread toward nearby …
such as DNA methylation that, in theory, have the potential to spread toward nearby …
Epigenetic mechanism causes Wnt9b deficiency and nonsyndromic cleft lip and palate in the A/WySn mouse strain
…, MJ Harris, DL Mager, L Gagnier - Birth Defects Research …, 2014 - Wiley Online Library
Background: The heritable multifactorial etiology of human nonsyndromic cleft lip with or
without cleft palate (CL ± P) is not understood. CL ± P occurs in 15% of neonates in the …
without cleft palate (CL ± P) is not understood. CL ± P occurs in 15% of neonates in the …
Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice
BACKGROUND Human nonsyndromic cleft lip and palate, CL(P), is genetically complex, with
one contributing gene on chromosome 17q. A potentially homologous gene, clf1 on distal …
one contributing gene on chromosome 17q. A potentially homologous gene, clf1 on distal …
Structure and expression of mobile ETnII retroelements and their coding-competent MusD relatives in the mouse
C Baust, L Gagnier, GJ Baillie, MJ Harris… - Journal of …, 2003 - Am Soc Microbiol
ETnII elements are mobile members of the repetitive early transposon family of mouse long
terminal repeat (LTR) retroelements and have caused a number of mutations by inserting …
terminal repeat (LTR) retroelements and have caused a number of mutations by inserting …