Enteric glia are a fascinating population of cells. Initially identified in the gut wall as the “support”
cells of the enteric nervous system, studies over the past 20 years have unveiled a vast …

Cell therapy has the potential to treat gastrointestinal motility disorders caused by diseases
of the enteric nervous system. Many studies have demonstrated that various stem/progenitor …

There are many different types of enteric neurons. Previous studies have identified the time
at which some enteric neuron subtypes are born (exit the cell cycle) in the mouse, but the …

Cell therapeutic approaches to treat a range of congenital and degenerative neuropathies
are under intense investigation. There have been recent significant advancements in the …

Various pathways enable communication between the gut and brain, and this
communication influences physiology and behaviour. Studies published in 2022 …

Background & Aims Cell therapy offers the potential to treat gastrointestinal motility disorders
caused by diseased or absent enteric neurons. We examined whether neurons generated …

An efficient delivery system is critical for the success of cell therapy. To deliver cells to a
dynamic organ, the biomaterial vehicle should mechanically match with the non-linearly elastic …

Background & Aims Hirschsprung disease (HSCR) is caused by failure of cells derived from
the neural crest (NC) to colonize the distal bowel in early embryogenesis, resulting in …

Cell therapy is a promising approach to generate an enteric nervous system (ENS) and treat
enteric neuropathies. However, for translation to the clinic, it is highly likely that enteric …

Patients with Hirschsprung disease lack enteric ganglia in the distal colon and propulsion of
colorectal content is substantially impaired. Proposed stem cell therapies to replace …