Omics data contain signals from the molecular, physical, and kinetic inter- and intracellular
interactions that control biological systems. Matrix factorization (MF) techniques can reveal …

The regulatory potential of RNA has never ceased to amaze: from RNA catalysis, to RNA-mediated
splicing, to RNA-based silencing of an entire chromosome during dosage …

10.7554/eLife.01749.001 Many studies are uncovering functional roles for long noncoding
RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in …

RNA, including long noncoding RNA (lncRNA), is known to be an abundant and important
structural component of the nuclear matrix. However, the molecular identities, functional roles …

DNA methylation was first described almost a century ago; however, the rules governing its
establishment and maintenance remain elusive. Here we present data demonstrating that …

The prevalence of obesity has led to a surge of interest in understanding the detailed
mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and …

MicroRNAs (miRNAs) are endogenous single-stranded RNA molecules of about 21
nucleotides in length that are fundamental post-transcriptional regulators of gene expression. …

Psychedelics are a broad class of drugs defined by their ability to induce an altered state of
consciousness 1 , 2 . These drugs have been used for millennia in both spiritual and …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity …

Noncoding RNAs have emerged as important key players in the cell. Understanding their
surprisingly diverse range of functions is challenging for experimental and computational …