A long-term aim of the life sciences is to understand how organismal shape is encoded by
the genome. An important challenge is to identify mechanistic links between the genes that …

… Interactions between primordial germ cells play a role in SW, and Tada, M. (2003). Prickle
1 … Leptin, M. (1991). twist and snail as positive and negative regulaHildebrand, JD, and …

… state of so-called leptin resistance. A number of mechanisms, including the leptin-stimulated …
signaling 3, attenuate leptin signaling and promote a cellular leptin resistance in obesity. …

… -band extension, however, twist products disappear from nonmesodermal cells; and
when the mesoderm has invaginated fully, the ruesectodermal cells no longer express twist (Leptin …

… (M – P) Later stages of germ band extension. In twist embryos, the epithelium that had …
cell interaction molecules plays no role in the first phase of gastrulation (Leptin et al. 1989). …

Background The zebrafish has become a widely used model to study disease resistance and
immunity. Although the genes encoding many components of immune signaling pathways …

The Rho GTPases mediate actin rearrangements that are likely to be required for the
numerous cell shape changes in a developing embryo. In a genetic screen for Rho signaling …

Background Members of the p47 (immunity-related GTPases (IRG) family) GTPases are
essential, interferon-inducible resistance factors in mice that are active against a broad spectrum …

… (H to M) Co-localization of PDZ domains with T48HA. S2 cells transfected with GFP-tagged
RhoGEF2-PDZ [(H) to (J)] or Scribbled-PDZ [(K) to (M)] alone or in combination with T48HA …

Background: The final shape and size of an organism is determined by both morphogenetic
processes and cell proliferation and it is essential that these processes be properly …