The quest for the ideal therapeutic target in chronic kidney disease (CKD) has been riddled
with many obstacles stemming from the molecular complexity of the disease and its co-…

Purpose Urine is considered to be produced predominantly as a result of plasma filtration in
the kidney. However, the origin of the native peptides present in urine has never been …

In the recent decades, the evolution of omics technologies has led to advances in all biological
fields, creating a demand for effective storage, management and exchange of rapidly …

Mechanisms underlying the onset and progression of nephropathy in diabetic patients are
not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease …

Purpose Urine is a rich source of potential biomarkers, including glycoproteins. Glycoproteomic
analysis remains difficult due to the high heterogeneity of glycans. Nevertheless, recent …

Renal Cysts and Diabetes Syndrome (RCAD) is an autosomal dominant disorder caused by
mutations in the HNF1B gene encoding for the transcriptional factor hepatocyte nuclear …

Introduction: Due to its close connection with the renal system, urine is considered a valuable
source of information in kidney disease research. Peptidomics methods focus on the …

A major challenge in cancer treatment is predicting the clinical response to anti-cancer drugs
for each individual patient. For complex diseases such as cancer, characterized by high …

IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide.
Although our understanding of IgAN has advanced significantly, its underlying biology and …

Non-invasive tools stratifying bladder cancer (BC) patients according to the risk of relapse
are urgently needed to guide clinical intervention. As a follow-up to the previously published …