Transmembrane member 16A (TMEM16A) is a widely expressed Ca 2+ -activated Cl −
channel with various physiological functions ranging from mucosal secretion to regulating …

In externally fertilizing animals, such as sea urchins and frogs, prolonged depolarization of
the egg immediately after fertilization inhibits the entry of additional sperm—a phenomenon …

10.7554/eLife.36491.001 Most eukaryotic parasites are obligately heteroxenous, requiring
sequential infection of different host species in order to survive. Toxoplasma gondii is a rare …

One of the earliest and most prevalent barriers to successful reproduction is polyspermy, or
fertilization of an egg by multiple sperm. To prevent these supernumerary fertilizations, eggs …

The prevention of polyspermy is essential for the successful progression of normal embryonic
development in most sexually reproducing species. In external fertilizers, the process of …

TransMEMbrane 16A (TMEM16A) is a Ca 2+ -activated Cl − channel that plays critical roles
in regulating diverse physiologic processes, including vascular tone, sensory signal …

Background The necessity of extracellular Ca 2+ for fertilization and early embryonic development
in the African clawed frog, Xenopus laevis, is controversial. Ca 2+ entry into X. laevis …

The Ca 2+-activated Cl-channel, TransMEMbrane member 16A (TMEM16A), regulates
diverse physiological functions including smooth muscle contraction, mucosal secretion and …

The Ca 2+-activated Cl-channel, TransMEMbrane member 16A (TMEM16A), regulates critical
functions including smooth muscle contraction, mucosal secretion, and signal transduction…

Tembo and Carlson reflect on recent work describing a new role for Ano1 in lymphatic
collecting vessels.