Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
…, ATA Sapone, M Thakar… - Scandinavian journal …, 2006 - Taylor & Francis
Objective. Little is known about the interaction of gliadin with intestinal epithelial cells and
the mechanism(s) through which gliadin crosses the intestinal epithelial barrier. We …
the mechanism(s) through which gliadin crosses the intestinal epithelial barrier. We …
[HTML][HTML] The active Zot domain (aa 288–293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding …
SE Goldblum, U Rai, A Tripathi, M Thakar… - The FASEB …, 2011 - ncbi.nlm.nih.gov
Vibrio cholerae-derived zonula occludins toxin (Zot) is a multifunctional protein that reversibly
disassembles intestinal tight junctions (tjs). Zot structure-function analysis has mapped this …
disassembles intestinal tight junctions (tjs). Zot structure-function analysis has mapped this …
Decitabine induces delayed reactive oxygen species (ROS) accumulation in leukemia cells and induces the expression of ROS generating enzymes
TE Fandy, A Jiemjit, M Thakar, P Rhoden, L Suarez… - Clinical Cancer …, 2014 - AACR
Purpose: Azanucleoside DNA methyltransferase (DNMT) inhibitors are currently approved
by the US Food and Drug Administration for treatment of myelodysplastic syndrome. The …
by the US Food and Drug Administration for treatment of myelodysplastic syndrome. The …
[HTML][HTML] Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection
…, AE Jedlicka, CA Caputo, KE Rousseau, M Thakar… - JCI insight, 2022 - ncbi.nlm.nih.gov
Benchmarks for protective immunity from infection or severe disease after SARS-CoV-2
vaccination are still being defined. Here, we characterized virus neutralizing and ELISA antibody …
vaccination are still being defined. Here, we characterized virus neutralizing and ELISA antibody …
Insulin‐like growth factor type 1 (IGF–1) and IGF binding protein–3 in patients with Ewing sarcoma family of tumors
JA Toretsky, SM Steinberg, M Thakar… - … Journal of the …, 2001 - Wiley Online Library
BACKGROUND Ewing sarcoma family of tumors (ESFTs) are the second most common
bone tumor, that most often affects persons ages 3–40 years. The ESFTs rely on signaling …
bone tumor, that most often affects persons ages 3–40 years. The ESFTs rely on signaling …
Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell …
…, J Perez, M Considine, M Thakar… - Cancer biology & …, 2015 - Taylor & Francis
Epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck
squamous cell carcinoma (HNSCC) and cetuximab, a monoclonal antibody targeting this …
squamous cell carcinoma (HNSCC) and cetuximab, a monoclonal antibody targeting this …
[HTML][HTML] Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance
Background Targeted therapies specifically act by blocking the activity of proteins that are
encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and …
encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and …
Phosphoinositide 3-hydroxide kinase blockade enhances apoptosis in the Ewing's sarcoma family of tumors
JA Toretsky, M Thakar, AE Eskenazi, CN Frantz - Cancer research, 1999 - AACR
Ewing’s sarcoma family of tumors (ESFTs) affects patients between the ages of 3 and 40
years, with most cases occurring in the second decade of life. These tumors contain a …
years, with most cases occurring in the second decade of life. These tumors contain a …
Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells
RF Souza, S Wang, M Thakar, KN Smolinski, J Yin… - Oncogene, 1999 - nature.com
The insulin-like growth factor II receptor (IGFIIR) has been implicated as a tumor suppressor
gene in human malignancy. Frequent mutation, loss of heterozygosity, and microsatellite …
gene in human malignancy. Frequent mutation, loss of heterozygosity, and microsatellite …
The impact of ΔG on the oral bioavailability of low bioavailable therapeutic agents
Low oral bioavailability continues to drive research toward identifying novel approaches to
enhance drug delivery. Over the past few years, emphasis on the use of absorption …
enhance drug delivery. Over the past few years, emphasis on the use of absorption …