[HTML][HTML] Multiple Sclerosis Risk Variant HLA-DRB1*1501 Associates with High Expression of DRB1 Gene in Different Human Populations
A Alcina, MM Abad-Grau, M Fedetz, G Izquierdo… - PloS one, 2012 - journals.plos.org
The human leukocyte antigen (HLA) DRB1*1501 has been consistently associated with
multiple sclerosis (MS) in nearly all populations tested. This points to a specific antigen …
multiple sclerosis (MS) in nearly all populations tested. This points to a specific antigen …
Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes
…, A Alcina, S Cañón, M Fedetz… - Nature structural & …, 2011 - nature.com
Many genomic alterations associated with human diseases localize in noncoding regulatory
elements located far from the promoters they regulate, making it challenging to link …
elements located far from the promoters they regulate, making it challenging to link …
[HTML][HTML] IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D)
A Alcina, M Fedetz, D Ndagire, O Fernández, L Leyva… - PLoS …, 2009 - journals.plos.org
Background IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R
system involved in the immune response and in the control of autoimmunity. Methods and …
system involved in the immune response and in the control of autoimmunity. Methods and …
[HTML][HTML] Evidence of conditioned behavior in amoebae
IM De la Fuente, C Bringas, I Malaina, M Fedetz… - Nature …, 2019 - nature.com
Associative memory is the main type of learning by which complex organisms endowed with
evolved nervous systems respond efficiently to certain environmental stimuli. It has been …
evolved nervous systems respond efficiently to certain environmental stimuli. It has been …
[HTML][HTML] Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13. 1
Multiple Sclerosis (MS) is the most common progressive and disabling neurological condition
affecting young adults in the world today. From a genetic point of view, MS is a complex …
affecting young adults in the world today. From a genetic point of view, MS is a complex …
Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis
A Alcina, M Fedetz, Ó Fernández, A Saiz… - Journal of medical …, 2013 - jmg.bmj.com
Background and aim Several studies have highlighted the association of the 12q13.3–12q14.1
region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (…
region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (…
SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κ B inhibition
M Karaky, M Fedetz, V Potenciano… - Human molecular …, 2018 - academic.oup.com
SP140 locus has been associated with multiple sclerosis (MS) as well as other autoimmune
diseases by genome-wide association studies (GWAS). The causal variant of these …
diseases by genome-wide association studies (GWAS). The causal variant of these …
[HTML][HTML] Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis
…, J Varadé, M García-Montojo, A Alcina, M Fedetz… - PloS one, 2014 - journals.plos.org
Background Human endogenous retroviruses (HERVs) are repetitive sequences derived
from ancestral germ-line infections by exogenous retroviruses and different HERV families …
from ancestral germ-line infections by exogenous retroviruses and different HERV families …
A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis
…, E Urcelay, M Comabella, A Alcina, M Fedetz… - Genes & …, 2012 - nature.com
Cytokine and cytokine receptor genes, including IL2RA, IL7R and IL12A, are known risk
factors for multiple sclerosis (MS). Excitotoxic oligodendroglial death mediated by glutamate …
factors for multiple sclerosis (MS). Excitotoxic oligodendroglial death mediated by glutamate …
A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis
F Matesanz, V Potenciano, M Fedetz… - Human molecular …, 2015 - academic.oup.com
Several variants in strong linkage disequilibrium (LD) at the SP140 locus have been associated
with multiple sclerosis (MS), Crohn's disease (CD) and chronic lymphocytic leukemia (…
with multiple sclerosis (MS), Crohn's disease (CD) and chronic lymphocytic leukemia (…