Assembly of branched actin filament networks at the leading edge of migrating cells requires
stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators …

Temporal and spatial control of the actin cytoskeleton are crucial for a range of eukaryotic
cellular processes. Capping protein (CP), a ubiquitous highly conserved heterodimer, tightly …

Cofilin is essential for cell viability and for actin-based motility. Cofilin severs actin filaments,
which enhances the dynamics of filament assembly. We investigated the mechanism of …

Cytoskeletal filaments are often capped at one end, regulating assembly and cellular location.
The actin filament is a right-handed, two-strand long-pitch helix [1]. The ends of the two …

Twinfilin is a ubiquitous actin monomer–binding protein that regulates actin filament turnover
in yeast and mammalian cells. To elucidate the mechanism by which twinfilin contributes to …

We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between
monomers and tetramers regulated by allosteric binding of naturally occurring small-molecule …

Infection by helminth parasites is associated with amelioration of allergic reactivity, but
mechanistic insights into this association are lacking. Products secreted by the mouse parasite …

Actin polymerization in cells occurs via filament elongation at the barbed end. Proteins that
cap the barbed end terminate this elongation. Heterodimeric capping protein (CP) is an …

To explore the variability in biosensor studies, 150 participants from 20 countries were given
the same protein samples and asked to determine kinetic rate constants for the interaction. …

Many pathogenic bacteria encase themselves in a polysaccharide capsule that provides a
barrier to the physical and immunological challenges of the host. The mechanism by which …