Formation, elimination and remodeling of excitatory synapses on dendritic spines represent
a continuous process that shapes the organization of synaptic networks during development…

Drug-evoked synaptic plasticity in the mesolimbic system reshapes circuit function and
drives drug-adaptive behavior. Much research has focused on excitatory transmission in the …

Background Recent experimental observations suggest that, in addition to induce neuroapoptosis,
anesthetics can also interfere with synaptogenesis during brain development. The …

Dendritic spines are the main postsynaptic site of excitatory contacts between neurons in
the central nervous system. On cortical neurons, spines undergo a continuous turnover …

Background Recent observations demonstrate that anesthetics rapidly impair synaptogenesis
during neuronal circuitry development. Whether these effects are lasting and depend on …

An increasing body of data has shown that matrix metalloproteinase-9 (MMP-9), an extracellularly
acting, Zn 2+ -dependent endopeptidase, is important not only for pathologies of the …

Experience-driven activity plays an essential role in the development of brain circuitry during
critical periods of early postnatal life, a process that depends upon a dynamic balance …

Abstract Development and remodeling of synaptic networks occurs through a continuous
turnover of dendritic spines. However, the mechanisms that regulate the formation and …

Excitatory synapses on dendritic spines are dynamic structures whose stability can vary from
hours to years. However, the molecular mechanisms regulating spine persistence remain …

Schizophrenia is a severely debilitating neurodevelopmental disorder. Establishing a
causal link between circuit dysfunction and particular behavioral traits that are relevant to …