We present a high-quality genome sequence of a Neanderthal woman from Siberia. We
show that her parents were related at the level of half-siblings and that mating among close …

High-throughput direct sequencing techniques have recently opened the possibility to
sequence genomes from Pleistocene organisms. Here we analyze DNA sequences determined …

The large amount of DNA sequence data generated by high-throughput sequencing technologies
often allows multiple samples to be sequenced in parallel on a single sequencing run. …

Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of
Europe and western Asia before disappearing 30,000 years ago. We present a draft …

Although an inverse relationship is expected in ancient DNA samples between the number
of surviving DNA fragments and their length, ancient DNA sequencing libraries are strikingly …

Excavations of a complex of caves in the Sierra de Atapuerca in northern Spain have unearthed
hominin fossils that range in age from the early Pleistocene to the Holocene 1 . One of …

This protocol describes a method for converting short single-stranded and double-stranded
DNA into libraries compatible with high-throughput sequencing using Illumina technology. …

This paper presents an in-depth study of Surface Enhanced Raman Scattering (SERS)
enhancement factors (EFs) and cross-sections, including several issues often overlooked. In …

Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have
sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual …

We present a DNA library preparation method that has allowed us to reconstruct a high-coverage
(30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality …