Retinoid signaling determines germ cell fate in mice
Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on
molecular cues that have not been identified. We found that retinoic acid, produced by …
molecular cues that have not been identified. We found that retinoic acid, produced by …
[HTML][HTML] Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data
High-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric pressure)
exerts severe physiological stress on the human body. Two high-altitude regions where …
exerts severe physiological stress on the human body. Two high-altitude regions where …
[HTML][HTML] Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination
We have raised an antibody specifically recognizing endogenous mouse SRY protein and
used it to investigate the molecular and cellular mode of action of SRY in testis determination. …
used it to investigate the molecular and cellular mode of action of SRY in testis determination. …
Iron transport and regulation, cell signalling and genomics: lessons from Escherichia coli and Pseudomonas
A variety of bacterial species secrete and take up chelating compounds that enable
acquisition of iron (siderophores). It has become clear that a common feature in regulation of …
acquisition of iron (siderophores). It has become clear that a common feature in regulation of …
[HTML][HTML] Identifying positive selection candidate loci for high-altitude adaptation in Andean populations
High-altitude environments (>2,500 m) provide scientists with a natural laboratory to study
the physiological and genetic effects of low ambient oxygen tension on human populations. …
the physiological and genetic effects of low ambient oxygen tension on human populations. …
Characterization of an Endoprotease (PrpL) Encoded by a PvdS-Regulated Gene in Pseudomonas aeruginosa
…, AI Vasil, Z Johnson, MJ Wilson… - Infection and …, 2001 - Am Soc Microbiol
The expression of many virulence factors in Pseudomonas aeruginosa is dependent upon
environmental conditions, including iron levels, oxygen, temperature, and osmolarity. The …
environmental conditions, including iron levels, oxygen, temperature, and osmolarity. The …
Andean and Tibetan patterns of adaptation to high altitude
Objectives High‐altitude hypoxia, or decreased oxygen levels caused by low barometric
pressure, challenges the ability of humans to live and reproduce. Despite these challenges, …
pressure, challenges the ability of humans to live and reproduce. Despite these challenges, …
Patterns of conservation and change in honey bee developmental genes
PK Dearden, MJ Wilson, L Sablan… - Genome …, 2006 - genome.cshlp.org
The current insect genome sequencing projects provide an opportunity to extend studies of
the evolution of developmental genes and pathways in insects. In this paper we examine the …
the evolution of developmental genes and pathways in insects. In this paper we examine the …
Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth
The effect of high altitude on reducing birth weight is markedly less in populations of high- (eg,
Andeans) relative to low-altitude origin (eg, Europeans). Uterine artery (UA) blood flow is …
Andeans) relative to low-altitude origin (eg, Europeans). Uterine artery (UA) blood flow is …
Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude
Reduced uteroplacental blood flow is hypothesized to play a key role in altitude-associated
fetal growth restriction. It is unknown whether reduced blood flow is a cause or consequence …
fetal growth restriction. It is unknown whether reduced blood flow is a cause or consequence …