Background Gene set scoring provides a useful approach for quantifying concordance
between sample transcriptomes and selected molecular signatures. Most methods use …

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer,
ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little …

Background Each omics platform is now able to generate a large amount of data. Genomics,
proteomics, metabolomics, interactomics are compiled at an ever increasing pace and now …

Natural killer (NK) cell activity is essential for initiating antitumor responses and may be
linked to immunotherapy success. NK cells and other innate immune components could be …

… Davis Melissa Davis is a computational cell biologist with research interests in genome-scale
biological network and pathway analysis, and the integration of experimental data with …

The mammary epithelium comprises two primary cellular lineages, but the degree of
heterogeneity within these compartments and their lineage relationships during development …

Background Altered networks of gene regulation underlie many complex conditions, including
cancer. Inferring gene regulatory networks from high-throughput microarray expression …

Background Aberrant changes in epigenetic mechanisms such as histone modifications play
an important role in cancer progression. PRMT1 which triggers asymmetric dimethylation of …

Caveolin proteins drive formation of caveolae, specialized cell-surface microdomains that
influence cell signaling. Signaling proteins are proposed to use conserved caveolin-binding …

To identify biologically relevant groupings or clusters of nuclear receptors (NR) that are
associated with breast neoplasia, with potentially diagnostic, discriminant or prognostic value, we …