Microtubules are structural polymers inside of cells that are subject to posttranslational
modifications. These posttranslational modifications create functionally distinct subsets of …

TPX2 is a widely conserved microtubule-associated protein that is required for mitotic spindle
formation and function. Previous studies have demonstrated that TPX2 is required for the …

The exocyst complex plays a critical role in determining both temporal and spatial dynamics
of exocytic vesicle tethering and fusion with the plasma membrane. However, the …

Extracellular netrin-1 and its receptor deleted in colorectal cancer (DCC) promote axon
branching in developing cortical neurons. Netrin-dependent morphogenesis is preceded by …

Kinesin-14 molecular motors represent an essential class of proteins that bind microtubules
and walk toward their minus-ends. Previous studies have described important roles for …

Schizophrenia is a severe and heritable neuropsychiatric disorder, which arises due to a
combination of common genetic variation, rare loss of function variation, and copy number …

TSNARE1, which encodes the protein tSNARE1, is a high-confidence gene candidate for
schizophrenia risk, but nothing is known about its cellular or physiological function. We …

The synthesis and characterization of two copper(II) complexes containing 2-(2-pyridyl)benzimidazole
(PyBIm) are reported with the biological activity of these two complexes and a …

Stathmin/Oncoprotein 18, a microtubule destabilizing protein, is required for survival of p53-deficient
cells. Stathmin-depleted cells are slower to enter mitosis, but whether delayed …

Schizophrenia is a severe and heritable neuropsychiatric disorder. Genome-wide association
studies identified 145 loci within the genome as associated with schizophrenia, implicating …