In embryonic stem (ES) cells and in early mouse embryos, the transcription factor Oct4 is an
essential regulator of pluripotency. Oct4 transcriptional targets have been described in ES …

We here identify and characterize an extracellular modulator of Hedgehog signaling in
Drosophila, Shifted. Shifted is required for high levels of long-range signaling in the developing …

The reprogramming factors OCT4, SOX2, KLF4, and MYC (OSKM) can reactivate the
pluripotency network in terminally differentiated cells, but also regulate expression of non-…

Pioneer transcription factors (TFs), such as OCT4 and SOX2, play crucial roles in pluripotency
regulation. However, the master TF-governed pluripotency regulatory circuitry was largely …

An unintended consequence of fish stocking is genetic homogenization from interbreeding
between indigenous populations and genetically distinct hatchery strains. Lake trout …

The inner cell mass ( ICM ) of the mammalian blastocyst contains pluripotent epiblast ( EPI )
and differentiating primitive endoderm ( PE ) cells, intermingled like salt and pepper. In …

The practice of supplementing wild populations with captive-raised individuals is often intended
to rebuild reduced populations, but has many unintended negative outcomes, including …

Learning to write a scientific manuscript is one of the most important and rewarding scientific
training experiences, yet most young scientists only embark on this experience relatively …

During development, progenitors of embryonic stem (ES) and extraembryonic endoderm
stem (XEN) cells are concomitantly specified within the inner cell mass (ICM) of the mouse …

… Michael Halbisen, and all members of the Ralston lab for giving me the opportunity to fall in
love with science. Drs. Karen Hedin, Luis Lujan, Jim Maher, and Dennis Mays for equipping …