[HTML][HTML] Separation of submicron bioparticles by dielectrophoresis
Submicron particles such as latex spheres and viruses can be manipulated and characterized
using dielectrophoresis. By the use of appropriate microelectrode arrays, particles can be …
using dielectrophoresis. By the use of appropriate microelectrode arrays, particles can be …
Strategies for dielectrophoretic separation in laboratory‐on‐a‐chip systems
MP Hughes - Electrophoresis, 2002 - Wiley Online Library
Dielectrophoresis – the induced motion of polarizable particles in nonuniform fields – has
proven to be an effective method for the separation of bioparticles such as cells, viruses and …
proven to be an effective method for the separation of bioparticles such as cells, viruses and …
[PDF][PDF] The expanding amyloid family: Structure, stability, function, and pathogenesis
MR Sawaya, MP Hughes, JA Rodriguez, R Riek… - Cell, 2021 - cell.com
The hidden world of amyloid biology has suddenly snapped into atomic-level focus, revealing
over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular proteins, …
over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular proteins, …
Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks
Subcellular membraneless assemblies are a reinvigorated area of study in biology, with
spirited scientific discussions on the forces between the low-complexity protein domains within …
spirited scientific discussions on the forces between the low-complexity protein domains within …
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation
The normally soluble TAR DNA-binding protein 43 (TDP-43) is found aggregated both in
reversible stress granules and in irreversible pathogenic amyloid. In TDP-43, the low-…
reversible stress granules and in irreversible pathogenic amyloid. In TDP-43, the low-…
Manipulation of herpes simplex virus type 1 by dielectrophoresis
The frequency-dependent dielectrophoretic behaviour of an enveloped mammalian virus,
herpes simplex virus type 1 is described. It is demonstrated that over the range 10 kHz–20 MHz…
herpes simplex virus type 1 is described. It is demonstrated that over the range 10 kHz–20 MHz…
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
TO Vogler, JR Wheeler, ED Nguyen, MP Hughes… - Nature, 2018 - nature.com
A dominant histopathological feature in neuromuscular diseases, including amyotrophic
lateral sclerosis and inclusion body myopathy, is cytoplasmic aggregation of the RNA-binding …
lateral sclerosis and inclusion body myopathy, is cytoplasmic aggregation of the RNA-binding …
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure
Aggregation of α-synuclein is a defining molecular feature of Parkinson’s disease, Lewy body
dementia, and multiple systems atrophy. Hereditary mutations in α-synuclein are linked to …
dementia, and multiple systems atrophy. Hereditary mutations in α-synuclein are linked to …
Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta
10.7554/eLife.00857.001 Amyloid protein aggregates are associated with dozens of devastating
diseases including Alzheimer’s, Parkinson’s, ALS, and diabetes type 2. While structure-…
diseases including Alzheimer’s, Parkinson’s, ALS, and diabetes type 2. While structure-…
[HTML][HTML] CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid
hnRNPA2 is a human ribonucleoprotein (RNP) involved in RNA metabolism. It forms fibrils
both under cellular stress and in mutated form in neurodegenerative conditions. Previous …
both under cellular stress and in mutated form in neurodegenerative conditions. Previous …