User profiles for Michelle D. Brazas

Michelle D. Brazas

Senior Program Manager, Ontario Institute for Cancer Research
Verified email at oicr.on.ca
Cited by 2024

Swarming of Pseudomonas aeruginosa Is a Complex Adaptation Leading to Increased Production of Virulence Factors and Antibiotic Resistance

J Overhage, M Bains, MD Brazas, REW Hancock - 2008 - Am Soc Microbiol
In addition to exhibiting swimming and twitching motility, Pseudomonas aeruginosa is able
to swarm on semisolid (viscous) surfaces. Recent studies have indicated that swarming is a …

Contribution of the PhoP-PhoQ and PmrA-PmrB Two-Component Regulatory Systems to Mg2+-Induced Gene Regulation in Pseudomonas aeruginosa

…, S Lewenza, A Kwasnicka, MD Brazas… - Journal of …, 2006 - Am Soc Microbiol
When grown in divalent cation-limited medium, Pseudomonas aeruginosa becomes resistant
to cationic antimicrobial peptides and polymyxin B. This resistance is regulated by the …

Ciprofloxacin Induction of a Susceptibility Determinant in Pseudomonas aeruginosa

MD Brazas, REW Hancock - Antimicrobial agents and …, 2005 - Am Soc Microbiol
With few novel antimicrobials in development, resistance to the current selection of antibiotics
increasingly encroaches on our ability to control microbial infections. One limitation in our …

A global perspective on evolving bioinformatics and data science training needs

TK Attwood, S Blackford, MD Brazas… - Briefings in …, 2019 - academic.oup.com
Bioinformatics is now intrinsic to life science research, but the past decade has witnessed a
continuing deficiency in this essential expertise. Basic data stewardship is still taught …

Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance

MD Brazas, REW Hancock - Drug discovery today, 2005 - Elsevier
Microarray analyses reveal global changes in gene expression in response to environmental
changes and, thus, are well suited to providing a detailed picture of bacterial responses to …

[HTML][HTML] The development and application of bioinformatics core competencies to improve bioinformatics training and education

N Mulder, R Schwartz, MD Brazas… - PLoS computational …, 2018 - journals.plos.org
Bioinformatics is recognized as part of the essential knowledge base of numerous career
paths in biomedical research and healthcare. However, there is little agreement in the field …

Grand challenges in bioinformatics education and training

EB Işık, MD Brazas, R Schwartz, B Gaeta… - Nature …, 2023 - nature.com
With the increasing need for bioinformatics expertise in the life sciences, a coordinated effort
is needed to proactively and critically reflect on the challenges of educating and training life …

Best practices in bioinformatics training for life scientists

…, E Bongcam-Rudloff, MD Brazas… - Briefings in …, 2013 - academic.oup.com
The mountains of data thrusting from the new landscape of modern high-throughput biology
are irrevocably changing biomedical research and creating a near-insatiable demand for …

Role of Lon, an ATP-Dependent Protease Homolog, in Resistance of Pseudomonas aeruginosa to Ciprofloxacin

MD Brazas, EBM Breidenstein… - Antimicrobial agents …, 2007 - Am Soc Microbiol
With few novel antimicrobials in the pharmaceutical pipeline, resistance to the current
selection of antibiotics represents a significant therapeutic challenge. Microbial persistence in …

Metabolic Changes Associated With Adaptive Diversification in Escherichia coli

M Le Gac, MD Brazas, M Bertrand, JG Tyerman… - Genetics, 2008 - academic.oup.com
During a 1000-generation evolution experiment, two types of morphologically and kinetically
distinct bacteria repeatedly diverged from a common ancestor in a fully sympatric seasonal …