User profiles for Michelle D. Brazas
Michelle D. BrazasSenior Program Manager, Ontario Institute for Cancer Research Verified email at oicr.on.ca Cited by 2024 |
Swarming of Pseudomonas aeruginosa Is a Complex Adaptation Leading to Increased Production of Virulence Factors and Antibiotic Resistance
In addition to exhibiting swimming and twitching motility, Pseudomonas aeruginosa is able
to swarm on semisolid (viscous) surfaces. Recent studies have indicated that swarming is a …
to swarm on semisolid (viscous) surfaces. Recent studies have indicated that swarming is a …
Contribution of the PhoP-PhoQ and PmrA-PmrB Two-Component Regulatory Systems to Mg2+-Induced Gene Regulation in Pseudomonas aeruginosa
When grown in divalent cation-limited medium, Pseudomonas aeruginosa becomes resistant
to cationic antimicrobial peptides and polymyxin B. This resistance is regulated by the …
to cationic antimicrobial peptides and polymyxin B. This resistance is regulated by the …
Ciprofloxacin Induction of a Susceptibility Determinant in Pseudomonas aeruginosa
MD Brazas, REW Hancock - Antimicrobial agents and …, 2005 - Am Soc Microbiol
With few novel antimicrobials in development, resistance to the current selection of antibiotics
increasingly encroaches on our ability to control microbial infections. One limitation in our …
increasingly encroaches on our ability to control microbial infections. One limitation in our …
A global perspective on evolving bioinformatics and data science training needs
TK Attwood, S Blackford, MD Brazas… - Briefings in …, 2019 - academic.oup.com
Bioinformatics is now intrinsic to life science research, but the past decade has witnessed a
continuing deficiency in this essential expertise. Basic data stewardship is still taught …
continuing deficiency in this essential expertise. Basic data stewardship is still taught …
Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance
MD Brazas, REW Hancock - Drug discovery today, 2005 - Elsevier
Microarray analyses reveal global changes in gene expression in response to environmental
changes and, thus, are well suited to providing a detailed picture of bacterial responses to …
changes and, thus, are well suited to providing a detailed picture of bacterial responses to …
[HTML][HTML] The development and application of bioinformatics core competencies to improve bioinformatics training and education
N Mulder, R Schwartz, MD Brazas… - PLoS computational …, 2018 - journals.plos.org
Bioinformatics is recognized as part of the essential knowledge base of numerous career
paths in biomedical research and healthcare. However, there is little agreement in the field …
paths in biomedical research and healthcare. However, there is little agreement in the field …
Grand challenges in bioinformatics education and training
With the increasing need for bioinformatics expertise in the life sciences, a coordinated effort
is needed to proactively and critically reflect on the challenges of educating and training life …
is needed to proactively and critically reflect on the challenges of educating and training life …
Best practices in bioinformatics training for life scientists
…, E Bongcam-Rudloff, MD Brazas… - Briefings in …, 2013 - academic.oup.com
The mountains of data thrusting from the new landscape of modern high-throughput biology
are irrevocably changing biomedical research and creating a near-insatiable demand for …
are irrevocably changing biomedical research and creating a near-insatiable demand for …
Role of Lon, an ATP-Dependent Protease Homolog, in Resistance of Pseudomonas aeruginosa to Ciprofloxacin
MD Brazas, EBM Breidenstein… - Antimicrobial agents …, 2007 - Am Soc Microbiol
With few novel antimicrobials in the pharmaceutical pipeline, resistance to the current
selection of antibiotics represents a significant therapeutic challenge. Microbial persistence in …
selection of antibiotics represents a significant therapeutic challenge. Microbial persistence in …
Metabolic Changes Associated With Adaptive Diversification in Escherichia coli
During a 1000-generation evolution experiment, two types of morphologically and kinetically
distinct bacteria repeatedly diverged from a common ancestor in a fully sympatric seasonal …
distinct bacteria repeatedly diverged from a common ancestor in a fully sympatric seasonal …