[HTML][HTML] Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior
…, S Chandrasekaran, KJ Norman, MR Smith… - Nature …, 2020 - nature.com
Social isolation during the juvenile critical window is detrimental to proper functioning of the
prefrontal cortex (PFC) and establishment of appropriate adult social behaviors. However, …
prefrontal cortex (PFC) and establishment of appropriate adult social behaviors. However, …
Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation
…, J Short, K Caro, SE McCraney, C Cho, MR Smith… - Science …, 2021 - science.org
Cognitive function depends on frontal cortex development; however, the mechanisms
driving this process are poorly understood. Here, we identify that dynamic regulation of the …
driving this process are poorly understood. Here, we identify that dynamic regulation of the …
[HTML][HTML] Pharmacological risk factors associated with hospital readmission rates in a psychiatric cohort identified using prescriptome data mining
…, KW Johnson, BS Glicksberg, MR Smith… - BMC Medical Informatics …, 2018 - Springer
Background Worldwide, over 14% of individuals hospitalized for psychiatric reasons have
readmissions to hospitals within 30 days after discharge. Predicting patients at risk and …
readmissions to hospitals within 30 days after discharge. Predicting patients at risk and …
[HTML][HTML] Integrative bioinformatics identifies postnatal lead (Pb) exposure disrupts developmental cortical plasticity
MR Smith, P Yevoo, M Sadahiro, C Austin… - Scientific Reports, 2018 - nature.com
Given that thousands of chemicals released into the environment have the potential capacity
to harm neurodevelopment, there is an urgent need to systematically evaluate their toxicity. …
to harm neurodevelopment, there is an urgent need to systematically evaluate their toxicity. …
Integrative analysis of disease signatures shows inflammation disrupts juvenile experience-dependent cortical plasticity
Throughout childhood and adolescence, periods of heightened neuroplasticity are critical
for the development of healthy brain function and behavior. Given the high prevalence of …
for the development of healthy brain function and behavior. Given the high prevalence of …
Critical period plasticity-related transcriptional aberrations in schizophrenia and bipolar disorder
… Author links open overlay panel Milo R. Smith a b c d e f g h , Ben Readhead b g , Joel T. …
a subset of data that included the average age covariates showed a R 2 = −0.05 (p = 0.54) and …
a subset of data that included the average age covariates showed a R 2 = −0.05 (p = 0.54) and …
Loss-of-function of neuroplasticity-related genes confers risk for human neurodevelopmental disorders
High and increasing prevalence of neurodevelopmental disorders place enormous
personal and economic burdens on society. Given the growing realization that the roots of …
personal and economic burdens on society. Given the growing realization that the roots of …
Ontogeny of androgen receptor expression in spinal nucleus of the bulbocavernosus motoneurons and their target muscles in male mice
MR Smith, DK Hamson, JE Poort, CL Jordan… - Neuroscience …, 2012 - Elsevier
The spinal nucleus of the bulbocavernosus (SNB) in rodents is a neuromuscular system
consisting of lumbar motoneurons and the perineal muscles they innervate, the …
consisting of lumbar motoneurons and the perineal muscles they innervate, the …
[HTML][HTML] Systematic analysis of environmental chemicals that dysregulate critical period plasticity-related gene expression reveals common pathways that mimic …
MR Smith, P Yevoo, M Sadahiro, B Readhead… - Neural …, 2020 - hindawi.com
The tens of thousands of industrial and synthetic chemicals released into the environment
have an unknown but potentially significant capacity to interfere with neurodevelopment. …
have an unknown but potentially significant capacity to interfere with neurodevelopment. …
[PDF][PDF] Activation of somatostatin inhibitory neurons by Lypd6-nAChRα2 system restores juvenile-like plasticity in adult visual cortex
…, MP Demars, P Burman, P Yevoo, MR Smith… - bioRxiv, 2017 - scholar.archive.org
Heightened juvenile cortical plasticity declines into adulthood, posing a challenge for functional
recovery following brain injury or disease. A network of inhibition is critical for regulating …
recovery following brain injury or disease. A network of inhibition is critical for regulating …