[HTML][HTML] Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior

…, S Chandrasekaran, KJ Norman, MR Smith… - Nature …, 2020 - nature.com
Social isolation during the juvenile critical window is detrimental to proper functioning of the
prefrontal cortex (PFC) and establishment of appropriate adult social behaviors. However, …

Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation

…, J Short, K Caro, SE McCraney, C Cho, MR Smith… - Science …, 2021 - science.org
Cognitive function depends on frontal cortex development; however, the mechanisms
driving this process are poorly understood. Here, we identify that dynamic regulation of the …

[HTML][HTML] Pharmacological risk factors associated with hospital readmission rates in a psychiatric cohort identified using prescriptome data mining

…, KW Johnson, BS Glicksberg, MR Smith… - BMC Medical Informatics …, 2018 - Springer
Background Worldwide, over 14% of individuals hospitalized for psychiatric reasons have
readmissions to hospitals within 30 days after discharge. Predicting patients at risk and …

[HTML][HTML] Integrative bioinformatics identifies postnatal lead (Pb) exposure disrupts developmental cortical plasticity

MR Smith, P Yevoo, M Sadahiro, C Austin… - Scientific Reports, 2018 - nature.com
Given that thousands of chemicals released into the environment have the potential capacity
to harm neurodevelopment, there is an urgent need to systematically evaluate their toxicity. …

Integrative analysis of disease signatures shows inflammation disrupts juvenile experience-dependent cortical plasticity

MR Smith, P Burman, M Sadahiro, BA Kidd, JT Dudley… - eneuro, 2016 - eneuro.org
Throughout childhood and adolescence, periods of heightened neuroplasticity are critical
for the development of healthy brain function and behavior. Given the high prevalence of …

Critical period plasticity-related transcriptional aberrations in schizophrenia and bipolar disorder

MR Smith, B Readhead, JT Dudley, H Morishita - Schizophrenia research, 2019 - Elsevier
… Author links open overlay panel Milo R. Smith a b c d e f g h , Ben Readhead b g , Joel T. …
a subset of data that included the average age covariates showed a R 2 = −0.05 (p = 0.54) and …

Loss-of-function of neuroplasticity-related genes confers risk for human neurodevelopmental disorders

MR Smith, BS Glicksberg, L Li, R Chen… - … 2018: Proceedings of …, 2018 - World Scientific
High and increasing prevalence of neurodevelopmental disorders place enormous
personal and economic burdens on society. Given the growing realization that the roots of …

Ontogeny of androgen receptor expression in spinal nucleus of the bulbocavernosus motoneurons and their target muscles in male mice

MR Smith, DK Hamson, JE Poort, CL Jordan… - Neuroscience …, 2012 - Elsevier
The spinal nucleus of the bulbocavernosus (SNB) in rodents is a neuromuscular system
consisting of lumbar motoneurons and the perineal muscles they innervate, the …

[HTML][HTML] Systematic analysis of environmental chemicals that dysregulate critical period plasticity-related gene expression reveals common pathways that mimic …

MR Smith, P Yevoo, M Sadahiro, B Readhead… - Neural …, 2020 - hindawi.com
The tens of thousands of industrial and synthetic chemicals released into the environment
have an unknown but potentially significant capacity to interfere with neurodevelopment. …

[PDF][PDF] Activation of somatostatin inhibitory neurons by Lypd6-nAChRα2 system restores juvenile-like plasticity in adult visual cortex

…, MP Demars, P Burman, P Yevoo, MR Smith… - bioRxiv, 2017 - scholar.archive.org
Heightened juvenile cortical plasticity declines into adulthood, posing a challenge for functional
recovery following brain injury or disease. A network of inhibition is critical for regulating …